Environmental Analysis Health and Toxicology

The Korean Society of Environmental Health and Toxicology (환경독성보건학회)
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Bacterial Reverse Mutation Test of 1,2,4-trimethylbenzene

1,2,4-trimethylbenzene의 미생물복귀돌연변이시험

  • Kim, Soo-Jin (Toxicological Research Team, Chemical Safety&Health Center, Occupational Safety & Health Research Institute) ;
  • Cho, Hae-Won (Toxicological Research Team, Chemical Safety&Health Center, Occupational Safety & Health Research Institute) ;
  • Rim, Kyung-Taek (Toxicological Research Team, Chemical Safety&Health Center, Occupational Safety & Health Research Institute) ;
  • Maeng, Seung-Hee (Toxicological Research Team, Chemical Safety&Health Center, Occupational Safety & Health Research Institute) ;
  • Kim, Hyeon-Yeong (Toxicological Research Team, Chemical Safety&Health Center, Occupational Safety & Health Research Institute)
  • 김수진 (산업안전보건연구원 화학물질안전보건센터 독성연구팀) ;
  • 조해원 (산업안전보건연구원 화학물질안전보건센터 독성연구팀) ;
  • 임경택 (산업안전보건연구원 화학물질안전보건센터 독성연구팀) ;
  • 맹승희 (산업안전보건연구원 화학물질안전보건센터 독성연구팀) ;
  • 김현영 (산업안전보건연구원 화학물질안전보건센터 독성연구팀)
  • Published : 2006.12.31
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Abstract

We have investigated the genotoxicity of 1,2,4-trimethylbenzene using Ames reverse mutation test. In Ames reverse mutation test, 1,2,4-trimethylbenzene treatment at the dose of 100, 50, 25, 12.5, $6.25{\mu}g/plate$ did not induce mutagenicity in Salmonella typhimurium TA98, TA100, TA1535, TA1537 and in Escherichia coli WP2uvrA with and without metabolic activation. These results indicate that 1,2,4-trimethylbenzene has no mutagenic potential under the rendition in this study.

Keywords

References

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