Serum PCDDs/PCDFs Levels for the Residents Living in the Vicinity and Workers of the Municipal Waste Incinerators in Seoul, Korea

자원회수시설 근로자 및 인근 거주 주민의 혈중 다이옥신 농도 분포

  • Yang, Ji-Yeon (The Institute for Environmental Research, Yonsei University, College of Medicine) ;
  • Lim, Young-Ook (The Institute for Environmental Research, Yonsei University, College of Medicine) ;
  • Chang, Yoon-Seok (School of Environmental Engineering, Pohang University of Science and Technology) ;
  • Kim, Chang-Soo (Department of Prevent Medicine, College of Medicine, Yonsei University) ;
  • Shin, Dong-Chun (The Institute for Environmental Research, Yonsei University, College of Medicine)
  • 양지연 (연세대학교 의과대학 환경공해연구소) ;
  • 임영욱 (연세대학교 의과대학 환경공해연구소) ;
  • 장윤석 (포항공과대학 환경공학과) ;
  • 김창수 (연세대학교 의과대학 예방의학교실) ;
  • 신동천 (연세대학교 의과대학 환경공해연구소)
  • Published : 2006.12.31

Abstract

이 연구의 목적은 자원회수시설 근로자 및 인근 지역 거주 주민의 혈중다이옥신류 농도를 평가하고, 혈중 다이옥신류 농도에 영향을 미치는 요인을 평가하는 것이다. $2002{\sim}2004$년까지 대상 자원회수시설에 3년 이상 근무한 근로자 31명과 시설로부터 300 m이내 지역에서 3년 이상 거주한 주민 68명을 선정하여 혈액을 채취하였다. 참고 자료로 대상 자원회수시설에 영향을 받지 않는 도시 지역에 거주하는 일반 주민 11명을 함께 평가하였다. 혈액 채취 시 개인 특성에 대한 설문조사도 함께 실시하였다. 시설 근로자의 혈중 다이옥신류 농도는 평균 $2.09{\sim}66.67pg/g$ lipid, 인근 거주 주민은 $1.00{\sim}29.33pg/g$ lipid, 일반 도시 주민은 $5.29{\sim}35.93pg/g$ lipid로 측정되었다. 시설 인근 지역 거주 주민 및 일반 도시 주민 중 비 흡연자의 인체 부하량은 각각 3.0 ng TEQ/g lipid와 4.5 ng TEQ/g lipid로 평가되었다. 대상군의 특성에 따른 혈중 다이옥신류 농도 차이는 관찰되지 않았으며, 연령과 유의한 양의 상관성이 있었다.

Keywords

References

  1. Abraham A, Knoll A and Ende M. Intake, fecal excretion, and body burden of polychlorinated dibenzo-p-dioxins and dibenzofurans in breast-fed and formula-fed infants. Pediatric Research 1996; 40(5): 671-679 https://doi.org/10.1203/00006450-199611000-00005
  2. Birnbaum LS. Risk assessment and national status of dioxins : US Environmental Protection Agency's reassessment of dioxin and related compound. Proceeding POSTECH-Korea, 1997; pp. 29-70
  3. Becher H, Flesch-Janys D and Kauppinen T. Cancer mortality in German male workers exposed to phenoxy herbicides and dioxins. Cancer Causes Control 1996; 7: 312-321 https://doi.org/10.1007/BF00052936
  4. Bertazzi PA, Zocchetti C and Pesatori AC. Ten-year mortality study of the population involved in the Seveso incident in 1976. Am J Epidemiol 1989a; 129: 1187-1200 https://doi.org/10.1093/oxfordjournals.aje.a115240
  5. Bertazzi PA, Zocchetti C and Pesatori AC. Mortality in an area contaminated by TCDD following an industrial accident. Med Lav 1989b; 4: 316-329
  6. Bertazzi PA, Zocchetti C and Pesatori AC. Mortality of a young population after accidental exposure to 2, 3, 7, 8-tetrachlorodibenzodioxin. Int J Epidemiol 1992; 21: 118-123 https://doi.org/10.1093/ije/21.1.118
  7. Bertazzi PA, Pesatori AC and Consonni D. Cancer incidence in a population accidentally exposed to 2, 3, 7, 8-tetrachlorodibenzo-para-dioxin. Epidemiology 1993; 4(5): 398-406 https://doi.org/10.1097/00001648-199309000-00004
  8. Bertazzi PA, Zocchetti C and Guercilena S. Dioxin exposure and cancer risk: A 15-year mortality study after the 'Seveso Accident.' Epidemiology 1997; 8(6): 646-652 https://doi.org/10.1097/00001648-199710000-00006
  9. Bertazzi PA, Bernucci I and Brambilla G. The Seveso studies on early and long-term effects of dioxin exposure: a review. Environ Health Perspect 1998; 106(2): 625-633 https://doi.org/10.2307/3433813
  10. Bertazzi PA, Consonni D and Bachetti S. Health effects of dioxin exposure: a 20-year mortality study. Am J Epidemiol 2001a; 153(11): 1031-1044 https://doi.org/10.1093/aje/153.11.1031
  11. Bueno de Mesquita HB, Doornbos G and van der Kuip DM. Occupational exposure to phenoxy herbicides and chlorophenols and cancer mortality in the Netherlands. Am J Ind Med 1993; 23: 289-300 https://doi.org/10.1002/ajim.4700230206
  12. Caramaschi F, Corno G and Favaretti C. Chloracne following environmental contamination by TCDD in Seveso, Italy. Intl J Epidemiol 1981; 10: 135-143 https://doi.org/10.1093/ije/10.2.135
  13. Chen PH, Gaw JM and Wong CK. Levels and gas chromatographic patterns of polychlorinated biphenyls in the blood of patients after PCB poisoning in Taiwan. Bull Environ Contam Toxicol 1980; 25: 325-329 https://doi.org/10.1007/BF01985533
  14. Chen HL, Lee CC and Liao PC. Associations between dietary intake and serum polychlorinated dibenzo-p-dioxin and dibenzofuran (PCDD/F) levels in Taiwanese. Environmental Research 2003; 91: 172-178 https://doi.org/10.1016/S0013-9351(02)00058-0
  15. Cole DC, Kearney J, Ryan JJ and Gilman AP. Plasma levels and profiles of dioxin and dioxin-like compounds in Ontario Great Lakes anglers, Chemosphere 1997; 34(5-7): 1401-1409 https://doi.org/10.1016/S0045-6535(97)00437-2
  16. Deml E, Mangelsdorf I and Greim H. Chlorinated dibenzodioxins and disenzofurans (PCDD/F) in blood and human human milk of non occupationally exposed persons living in the vicinity of a municipal waste incinerator. Chemosphere 1996; 33: 1941-1950 https://doi.org/10.1016/0045-6535(96)00293-7
  17. Dewailly E, Nantel A and Brunea S. PCDDs, PCDFs and PCBs in Arctic Quebec : A Preliminary assessment. Chemosphere 1992; 25(7-10): 1245-1249 https://doi.org/10.1016/0045-6535(92)90467-6
  18. Ewers U, Wittsiepe J and Schrey P. Blood PCDD/F levels in blood of residents of a former cable incineration facility. Gesundheitswesen 1996; 58(8-9): 465-469
  19. Fingerhut MA, Halperin WE and Marlow DA. Cancer mortality in workers exposed to 2, 3, 7, 8-tetrachlorodibenzop-dioxin. N Engl J Med 1991; 324: 212-218 https://doi.org/10.1056/NEJM199101243240402
  20. Flesch-Janys D, Berger J and Gurn P. Exposure to polychlorinated dioxins and furans (PCDD/F) and mortality in a cohort of workers from a herbicide-producing plant in Hamburg, Federal Republic of Germany. Am J Epidemiol 1995; 142(11): 1165-1175 https://doi.org/10.1093/oxfordjournals.aje.a117575
  21. Flesch-Janys D, Steindorf K and Gurn P. Estimation of the cumulated exposure to polychlorinated dibenzo-p-dioxins/furans and standardized mortality ratio analysis of cancer mortality by dose in an occupationally exposed cohort. Environ Health Perspect 1998; 106(supplement 2): 655-662 https://doi.org/10.1289/ehp.98106655
  22. Flesch-Janys D, Becher J and Berger J. Epidemiological investigation of breast cancer incidence in a cohort of female workers with high exposure to PCDD/F and HCH. Organohalogen Compounds 1999; 44: 379-382
  23. Hooiveld M, Heederik DJ and Kogevinas M. Second follow -up of a Dutch cohort occupationally exposed to phenoxy herbicides, chlorophenols, and contaminants. Am J Epidemiol 1998; 147(9): 891-901 https://doi.org/10.1093/oxfordjournals.aje.a009543
  24. Hoover SM. Exposure to persistent organochlorines in Canadian breast milk : A probabilistic assessment. Risk Analysis 1999; 19(4): 527-545
  25. Iida T, Hirakawa H and Matsueda T. Polychlorinated dibenzo-p-dioxins and related compounds in breast milk of Japanese primiparas and multiparas. Chemosphere 1999; 38(11): 2461-2466 https://doi.org/10.1016/S0045-6535(98)00451-2
  26. Jimenez B, Hernandez LM and Eljarrat E. Levels of PCDDs, PCDFs and non-ortho PCBs in serum samples of nonexposed individuals living in Madrid (Spain). Chemosphere 1996; 33: 2403-2410 https://doi.org/10.1016/S0045-6535(96)00336-0
  27. Jimenez B, Wright C and Kelly M. Levels of PCDDs, PCDFs and non-ortho PCBs in dietary supplement fish oil obtained in Spain. Chemosphere 1996; 32(3): 461-467 https://doi.org/10.1016/0045-6535(95)00233-2
  28. Koda H and Masuda Y. Relation between PCB level in the blood and clinical symptoms of Yusho patients. Fukuoka Igaku Zasshi 1975; 55(10): 624-628
  29. Korric SA and Altshul L. High breast milk levels of poly-chlorinated biphenyls (PCBs) among four women living adjacent to a PCB-contaminated waste site. Environ. Health Persp. 1998; 106(8): 513-518 https://doi.org/10.2307/3434185
  30. Krauthacker B, Reiner E and Votava-Raic A. Organochlorine pesticides and PCBs in human milk collected from mothers nursing hospitalized children. Chemosphere 1998; 37(1): 27-32 https://doi.org/10.1016/S0045-6535(98)00035-6
  31. Kuratsune M, Masuda Y and Nagayama J. Some of the recent findings concerning Yusho: proceedings of National Conference on Polychlorinated Biphenyls, Nov. 19-21, Chicago, 1975
  32. Kuratsune M, Yoshimura H, Hori Y, Okumura Y and Masuda Y. Yusho: a human disaster caused by PCBs and related compounds. Kyushu University Press, Fukuoka, 1996
  33. Landi MT, Bertazzi PA and Consonni D. TCDD blood levels, population characteristics, and individual accident experience. Organohalogen Compounds 30: 290-293. Chlorophenol exposure in a community in southern Finland. Arch Environ Health 1996; 47(3): 167-175
  34. Landi MT, Consonni D and Patterson DG. Jr. 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin plasma levels in Seveso 20 years after the accident. Environ Health Perspect 1998; 106(5): 273-277 https://doi.org/10.2307/3434015
  35. Manz A, Berger J and Dwyer JH. Cancer mortality among workers in chemical plant contaminated with dioxin. Lancet 1991; 338: 959-964 https://doi.org/10.1016/0140-6736(91)91835-I
  36. Mocarelli P, Needham LL and Marocchi A. Serum concentrations of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin and test results from selected residents of Seveso, Italy. J Toxicol Environ Health 1991; 32: 357-366 https://doi.org/10.1080/15287399109531490
  37. Newsome WH, Davies DD and Doucet J. PCB and organochlorine pesticides in Canadian human milk-1992. Chemosphere 1995; 30(11): 2143-2153 https://doi.org/10.1016/0045-6535(95)00086-N
  38. Noren K and Meironyte D. Certain organochlorine and organobromine contaminants in Swedish human milk in perspective of past 20-30 years. Chemosphere 2000; 40: 1111-1123 https://doi.org/10.1016/S0045-6535(99)00360-4
  39. Okumura M. Past and current medical states of Yusho patients. Am J Ind Med 1984; 5: 13-18 https://doi.org/10.1002/ajim.4700050103
  40. Ott MG and Zober A. Cause specific mortality and cancer incidence among employees exposed to 2, 3, 7, 8-TCDD after a 1953 reactor accident. Occup Environ Med 1996; 53: 606-612 https://doi.org/10.1136/oem.53.9.606
  41. Papke O, Ball M, Lis A and Wuthe J. PCDD/PCDFs in humans, follow-up of background data for Germany, 1994, Chemosphere 1996; 32(3): 575-582 https://doi.org/10.1016/0045-6535(95)00320-7
  42. Papke O, Ball M and Lis A. PCDD/PCDF in humans, a 1993-update of background data. Chemosphere 1996; 29: 2355-2360 https://doi.org/10.1016/0045-6535(94)90404-9
  43. Patandin S, Dagnelie PC and Mulder PGH. Dietary exposure to polychlorinated biphenyls and dioxins from infancy until adulthood : A comparison between breastfeeding, toddler, and long-term exposure. Environ. Health Persp. 1999; 107(1): 45-51 https://doi.org/10.2307/3434288
  44. Patandin S, Dagnelie PC and Weisglas-Kuperus N. Exposure to PCBs, PCDDs and PCDFs through breast milk compared with long-term dietary exposure. Organohalogen Compounds 1998; 38: 214A-214E
  45. Pesatori AC, Consonni D and Tironi A. Cancer in a young population in a dioxin-contaminated area. Int J Epidemiol 1993; 22(6): 1010-1013 https://doi.org/10.1093/ije/22.6.1010
  46. Pesatori AC, Tironi A and Consonni A. Cancer incidence in the Seveso population, 1977-1991. Organohalogen Compounds 1999; 44: 411-412
  47. Rappe C. Dioxin, patterns and source identification. Fresenius' J Anal Chem 1994; 348: 63-75 https://doi.org/10.1007/BF00321606
  48. Schecter A, Papke O and Ryan JJ. Dioxins, dibenzofurans, and PCBs in human blood, human milk, and food from Israel, the Wesr Bank, and Gaza. Organohalogen Compounds 1997; 33: 457-459
  49. Schecter A, Ryan JJ and Papke O. Decrease in levels and body burden of dioxins, dibenzofurans, PCBs, DDE, and HCB in blood and milk in a mother nursing twins over a thirty-eight month period. Chemosphere 1998; 37(9-12): 1807-1816 https://doi.org/10.1016/S0045-6535(98)00246-X
  50. Schecter A, Papke O and Furst P. Tmporal changes in dioxin and dibenzofuran levels in General population human blood and milk from Germany and the United states. Organohalogen Compounds 1997; 33: 473-478
  51. Schuhmacher M, Domingo JL and Llobet JM. Dioxin and dibenzofuran concentrations in blood of a general population from Tarragona, Spain. Chemosphere 1999; 38(5): 1123-1133 https://doi.org/10.1016/S0045-6535(98)00363-4
  52. Somogyi A and Beck H. Nurtuning and breast-feeding : Exposure to chemicals in breast milk. Environ Health Persp 1993; 101(Suppl. 2): 45-52
  53. Steenland K, Piacitelli L and Deddens J. Cancer, heart disease, and diabetes in workers exposed to 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin. J Nat Cancer Ins 1999; 91 (9): 779-786 https://doi.org/10.1093/jnci/91.9.779
  54. Totaka. Concentrations of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and non-ortho and mono-ortho polychlorinated biphenyls in blood of Yusho patients. Chemosphere 2006; 66: 1983-1989
  55. Weisglas-Kuperus N. Neurodevelopmental, immunological and endocrinological induces of perinatal human exposure to PCBs and dioxins. Chemosphere 1998; 37(9-12): 1845-53 https://doi.org/10.1016/S0045-6535(98)00250-1
  56. Wuthe J, Piechotowski I and Papke O. First data on background levels of non-ortho and mono-ortho PCBS in blood of residents from Southern Germany. Chemosphere 1996; 32: 567-574 https://doi.org/10.1016/0045-6535(95)00351-7
  57. Yang JY, Shin DC and Park SE. PCDDs, PCDFs and PCBs concentrations in breast milk from two areas in Korea: body burden of mothers and implications for feeding infants. Chemosphere 2002; 46: 419-428 https://doi.org/10.1016/S0045-6535(01)00109-6
  58. Yoshida K, Ikeda S and Naksnishi J. Assessment of human health risk of dioxins in Japan. Chemosphere 2000; 40: 177-185 https://doi.org/10.1016/S0045-6535(99)00253-2
  59. Zober A, Messerer P and Huber P. Thirty-four-year mortality follow-up of BASF employees exposed to 2, 3, 7, 8-TCDD after the 1953 accident. Int Arch Occup Environ Health 1990; 62: 138-157
  60. Zuccato E, Calvarese S and Mariani G. Level, sources and toxicity of polychlorinated biphenyls in the Italian diet. Chemosphere 1999; 38(12): 2753-2765 https://doi.org/10.1016/S0045-6535(98)00477-9