Radiographic Estimation of Experimentally Induced Splenomegaly in Dogs

개에서 실험적으로 유발한 비장종대의 방사선학적 평가

  • Jung, In-Jo (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University) ;
  • Wang, Ji-Hwan (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University) ;
  • Yun, Je-Woong (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University) ;
  • Lee, Kyung-Woo (Department of Emergency medicine, College of Medicine, Gyeongsang National University) ;
  • Yeon, Seong-Chan (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University) ;
  • Lee, Hyo-Jong (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University) ;
  • Lee, Hee-Chun (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University)
  • 정인조 (경상대학교 수의과대학 동물의학연구소) ;
  • 왕지환 (경상대학교 수의과대학 동물의학연구소) ;
  • 윤제웅 (경상대학교 수의과대학 동물의학연구소) ;
  • 이경우 (경상대학교 의과대학 응급의학과) ;
  • 연성찬 (경상대학교 수의과대학 동물의학연구소) ;
  • 이효종 (경상대학교 수의과대학 동물의학연구소) ;
  • 이희천 (경상대학교 수의과대학 동물의학연구소)
  • Published : 2006.09.30

Abstract

The purpose of this study was to assess the usefulness of radiographic examination of the splenomegaly associated with drug-induced splenic congestion and to establish the standard goal of the splenomegaly in dogs. Radiographic images of spleen in normal dogs were collected to determine the maximum diameter prior to, and 15 minutes after, administration of acepromazine, ketamine/diazepam combination, or propofol. Significant splenic enlargement was seen after administration of acepromazine, but statistical signalficant was found in a ventrodorsal view only. Splenic size tended to decrease after administration of ketamine/diazepam combination. Significant splenic enlargement was not found after administration of propofol. These results suggest that measurable splenomegaly can be detected by radiographic examination after some kind of drug administration and the evaluation of splenomegaly is more useful at ventrodorsal view than lateral view.

Keywords

References

  1. Burk RL, Ackerman N. Small animal radiology and ultrasonography. ed. Philadelphia: WB Saunders Co. 1996: 410-414
  2. Couto CG. A diagnostic approach to splenomegaly in cats and dogs. Vet Med 1990; 85: 220-238
  3. Greenway CV, Splenic erythrocyte concentration mechanism and its inhibition by isoprotetnol. Am J Physiol 1979; 236: 238-243 https://doi.org/10.1152/ajpcell.1979.236.5.C238
  4. Hoka S, Yamaura K, Takenaka T, et al. Propofol-induced increase in vascular capacitance is due to inhibition of sympathetic vasoconstrictive activity. Anesthesiology 1998; 89: 1495-1500 https://doi.org/10.1097/00000542-199812000-00028
  5. Morgan DW, Legge K. Clinical evaluation of propofol as an intravenous anaesthetic agent in cats and dogs. Vet Rec 1989; 124: 31-33 https://doi.org/10.1136/vr.124.2.31
  6. Nyland TG, Mattoon JS. Small animal diagnostic ultrasound. 2nd ed. Philadelphia: WB Saunders Co. 2002: 131
  7. O'Brien RT, Waller III KR, Osgood TL. Sonographic features of drug-induced splenic congestion. Vet Radiol Ultrasound 2004; 45: 225-227 https://doi.org/10.1111/j.1740-8261.2004.04039.x
  8. Opadyke DF, Ward C. Spleen as an experimental model for the study of vascular capacitance. Am J Physiol 1973; 225: 1416-1420
  9. Parameswaran N, Hamlin R, Nakayama T, Rao SR. Increased splenic capacity in response to transdermal application of nitroglycerine in dog. J Vet Intern Med 1999; 13: 44-46 https://doi.org/10.1892/0891-6640(1999)013<0044:ISCIRT>2.3.CO;2
  10. Thorvaldson J, Stokland O, Ilebekk A. Effects of increased splenic arterial flow and venous pressure on splenic red cell accumulation. Am J Physiol 1990; 258: 669-678
  11. Thrall DE. Textbook of veterinary diagnostic radiology. 4th ed. Philadelphia: WB Saunders Co. 2002: 549
  12. Wilson DV, Evans AT, Carpenter RE, Mullineaux DR. The effect of four anesthetic protocols on splenic size in dogs. Vet Anaesth Analg 2004; 31: 102-108 https://doi.org/10.1111/j.1467-2987.2004.00152.x