Food Science and Biotechnology

Korean Society of Food Science and Technology (한국식품과학회)
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Assessment of the Potential Allergenicity of Genetically Modified Soybeans and Soy-based Products

  • Kim, Jae-Hwan (Graduate School of Biotechnology and Institute of Life Sciences and Resources, Department of Food Science and Biotechnology, Kyung Hee University) ;
  • Lieu, Hae-Youn (Graduate School of Biotechnology and Institute of Life Sciences and Resources, Department of Food Science and Biotechnology, Kyung Hee University) ;
  • Kim, Tae-Woon (Graduate School of Biotechnology and Institute of Life Sciences and Resources, Department of Food Science and Biotechnology, Kyung Hee University) ;
  • Kim, Dae-Ok (Graduate School of Biotechnology and Institute of Life Sciences and Resources, Department of Food Science and Biotechnology, Kyung Hee University) ;
  • Shon, Dong-Hwa (Food Function Research Division, Korea Food Research Institute) ;
  • Ahn, Kang-Mo (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Lee, Sang-Il (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Kim, Hae-Yeong (Graduate School of Biotechnology and Institute of Life Sciences and Resources, Department of Food Science and Biotechnology, Kyung Hee University)
  • Published : 2006.12.31
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Abstract

A comprehensive safety evaluation was conducted to assess the potential allergenicity of newly introduced proteins in genetically modified (GM) crops. We assessed the allergenicity of CP4 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) in GM soybeans. This assessment was performed by IgE immunoblotting with soy-allergic children's sera, amino acid sequence homology with known allergens, and the digestibility of CP4 EPSPS. No differences in IgE-antigen binding by immunoblotting were found between GM soy samples and the corresponding non-GM samples. Based on the comparison of EPSPS amino acid sequence homology with current allergen databases, no known allergen was found. In addition, CP4 EPSPS protein was rapidly digested by simulated gastric fluid (SGF). Taken together, these results indicate that GM soybeans have no allergenicity in children and are as safe as conventional soybeans.

Keywords

References

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