Annals of Rehabilitation Medicine

Korean Academy of Rehabilitation Medicine (대한재활의학회)
권호 표지

Clinical Features of Central Neuropathic Pain after Contusive Spinal Cord Injury in Rats

척수좌상 백서모델에서 중추 신경병증성 통증의 발현양상

Lee, So-Young;Im, Hyeong-Lyong;Kim, Jae-Hyung;Jung, Sung-Hwan;Choi, In-Sung;Lee, Sam-Gyu
이소영;임형룡;김재형;정성환;최인성;이삼규

  • Published : 20060000
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Abstract

Objective: To investigate the characteristics of the central neuropathic pain (CNP) after contusive spinal cord injury in rats. Method: Twenty Sprague-Dawley rats (300${\pm}$50 g, male) undergone the free-drop contusion injury from the dropheight of 2.5 cm at T10 cord (n=20) and ten rats undergone sham operation (n=10) were subjected to the neurobehavioral analyses by the Basso Beattie Bresnahan (BBB) locomotor rating scales, Touch testTM sensory evaluator (TTSE, North Coast Medical Inc., Canada) and Plantar test$^\circledR$ (Ugo Basile, Italy) after contusion at the 1$^{st}$, 3$^{rd}$, 5$^{th}$, 7$^{th}$, 14$^{th}$, 21$^{st}$ and 28$^{th}$ day. Results: The scores of BBB scales were the lowest at the 1$^{st}$ day and then slowly increased to spontaneous recovery state, but they were significantly lower than those of control group (p＜0.05). The thresholds of mechanical allodynia were significantly increased just after cord contusion, but progressed to decline, and significantly decreased after the 21$^{st}$ day (p＜0.05). The latencies of thermal hyperalgesia were delayed just after cord contusion, but significantly shorter than those of the control group after the 7$^{th}$ day (p＜ 0.05). Conclusion: These results would be helpful for the study of the CNP after contusive spinal cord injury in rats. (J Korean Acad Rehab Med 2006; 30: 142-147)

Keywords

References

  1. 이소영, 김지훈, 천승욱, 김재형, 최인성, 강경주, 이상규, 이민철, 김형범, 박승진: 척수좌상 유발장치에 의한 손상단계별 척수좌상 백서모델. 대한재활의학회지 2005; 29: 193-200
  2. Basso DM, Beattie MS, Bresnahan JC: Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection. Exp Neurol 1996; 139: 244-256 https://doi.org/10.1006/exnr.1996.0098
  3. Bruce JC, Oatway MA, Weaver LC: Chronic pain after cIipcompression injury of the rat spinal cord. Exp Neurol 2002; 178: 33-48 https://doi.org/10.1006/exnr.2002.8026
  4. Bryce TN, Ragnarsson KT: Pain after spinal cord injury. Phys Med Rehabil Clin N Am 2000; 11: 157-168 https://doi.org/10.1016/S1047-9651(18)30152-9
  5. Chapman V, Ng J, Dickenson AH: A novel spinal action of mexiletine in spinal somatosensory transmission of nerve injured rats. Pain 1998; 77: 289-296 https://doi.org/10.1016/S0304-3959(98)00106-7
  6. Christensen MD, Everhart AW, PickeIman JT, Hulsebosch CE: Mechanical and thermal allodynia in chronic central pain following spinal cord injury. Pain 1996; 68: 97-107 https://doi.org/10.1016/S0304-3959(96)03224-1
  7. Davidoff G, Roth E, Guarracini M, Sliwa J, Yarkony G: Function-limiting dysesthetic pain syndrome among traumatic spinal cord injury patients: a cross-sectional study. Pain 1987; 29: 39-48 https://doi.org/10.1016/0304-3959(87)90176-X
  8. Gwak YS, Nam TS, Paik KS, Hulsebosch CE, Leem JW: Attenuation of mechanical hyperalgesia following spinal cord injury by administration of antibodies to nerve growth factor in the rat. Neurosci Lett 2003; 336: 117-120 https://doi.org/10.1016/S0304-3940(02)01251-X
  9. Hains BC, Everhart AW, Fullwood SD, Hulsebosch CE: Changes in serotonin, serotonin transporter expression and serotonin denervation supersensitivity: involvement in chronic central pain after spinal hemisection in the rat. Exp Neurol 2002; 175: 347-362 https://doi.org/10.1006/exnr.2002.7892
  10. Hao JX, Yu W, Wiesenfeld-Hallin Z, Xu XJ: Treatment of chronic allodynia in spinally injured rats: effects of intrathecal selective opioid receptor agonists. Pain 1998; 75: 209-217 https://doi.org/10.1016/S0304-3959(97)00221-2
  11. Hulsebosch CE, Xu GY, Perez-polo JR, Westlund KN, Taylor CP, McaAdoo DJ: Rodent model of chronic central pain after spinal cord contusion injury and effects of gabapentin. J Neurotrauma 2000; 17: 1205-1217 https://doi.org/10.1089/neu.2000.17.1205
  12. Karen G, Harry K, Jean RW: Spinal cord contusion in the rat:behavioral analysis of functional neurologic impairment. Exp Neurol 1985; 88: 123-134 https://doi.org/10.1016/0014-4886(85)90118-9
  13. Mills CD, Grady JJ, Hulseboch CE: Changes in exploratory behavior as a measure of chronic central pain following spinal cord injury. J Neurotrauma 2001; 18: 1091-1105 https://doi.org/10.1089/08977150152693773
  14. Omana-Zapata I, Khabbaz MA, Hunter JC, Bley KR: QX-314 inhibits ectopic nerve activity associated with neuropathic pain. Brain Res 1997; 771: 228-237 https://doi.org/10.1016/S0006-8993(97)00770-1
  15. Siddall P, Xu CL, Cousins M: Allodynia following traumatic spinal cord injury in the rat. Neuroreport 1995; 19: 1241-1244
  16. Wall PD, Melzack R: Textbook of pain, 2nd ed, London: Churchill-Livingston, 1989, pp63-81
  17. Yezierski RP: Pain following spinal cord injury: pathophysiology and central mechanisms. Prog Brain Res 2000; 129: 429-449 https://doi.org/10.1016/S0079-6123(00)29033-X