Annals of Surgical Treatment and Research

The Korean Surgical Society (대한외과학회)
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The Effect of Preoperative Oral Application of Bovine Colostrum on Endotoxemia and TNF-${\alpha}$ in Abdominal Surgery

복부수술 전 젖소초유의 경구투여가 내독소혈증과 TNF-${\alpha}$에 미치는 영향

Seo, Hyun-Il;Jeon, Woo-Kyu;Kang, Jin-Ho;Lim, Si-Young;Lee, Seung-Sei;Sohn, Byung-Ho;Ryu, Chang-Hak;Shin, Jun-Ho;Kim, Hung-Dai;Han, Won-Kon;Oh, Tae-Yun;Woo, Hee-Yeon;Park, Hyo-Soon
서현일;전우규;강진호;임시영;이승세;손병호;류창학;신준호;김흥대;한원곤;오태윤;우희연;박효순

  • Published : 20060000
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Abstract

Purpose: We conducted this study to assess the effect of oral application of bovine colostrum on the plasma endotoxin and TNF-${\alpah}$ following the abdominal surgery. Methods: 46 patients who underwent the abdominal surgery were evenly enrolled in a prospective, randomized, double blind and placebo-controlled study. The patients were preoperatively managed by oral application of 20 g of a bovine colostrums or placebo (nonfat dried milk) per a day for 3 days. In both groups, endotoxin was sequentially determined pre-, intra- and postoperatively by a modified limulus amebocyte lysate test. TNF-${\alpah}$ and CRP were also measured. The clinical course was followed and compared in both groups. Results: The colostrum group showed significantly lower level of endotoxin and TNF-${\alpah}$ compared to the placebo group. CRP did not differ in both groups. Clinical event did not occur in both group until the discharge. Colostrum group tends to have a lower incidence of fever and leukocytosis without statistic significance. Conclusion: Prophylactic preoperative oral application of bovine colostrum lower the plasma level of perioperative endotoxin and TNF-${\alpah}$. Further studies were needed for the relation of clinical effect and preoperative oral application of bovine colostrum. (J Korean Surg Soc 2006;70:462-469)

Keywords

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