Annals of Laboratory Medicine

Korean Society for Laboratory Medicine (대한진단검사의학회)
권호 표지

Three Cases of Pseudoeosinophilia Associated with Malaria Determined in the Sysmex XE-2100 Automated Hematology Analyzer

Sysmex XE-2100 자동혈구분석기에서 가성호산구증가증을 보인 말라리아 3예

G. Park, Bo-Rae;Cha, Young-Joo
박금보래;차영주

  • Published : 20060000
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Abstract

In Korea, the incidence of malaria has been increasing in the civilian population and in the areas previously considered as noninfected. Malaria can be suspected based on the patient's symptoms and the physical findings at examination. However, for a definitive diagnosis to be made, the malaria parasites or their components must be demonstrated by laboratory tests, which will take time and require expertise. Since general screening tests, such as a complete blood cell count, are always done for patients with a fever, it can be expected that the attention of laboratory hematologists drawn to any abnormalities found in automated hematology analyzers can help reduce delays in the diagnosis of malaria even if such a diagnosis was not initially considered. We report three cases of malaria that had thrombocytopenia and pseudoeosinophilia shown in the Sysmex XE-2100 (TOA Medical Electronics, Kobe, Japan) automated hematology analyzer. It is feasible that the pseudoeosinophilia presented as a result of hemozoin-containing white blood cells may contribute to the diagnosis of malaria, especially for patients unsuspected of the disease.

우리나라에서는 현재 꾸준히 말라리아가 발병되고 있고, 특히 민간인과 감염지역이 아닌 지역에서 말라리아가 증가하고 있는 실정이다. 말라리아의 진단을 위하여서는 임상증상과 함께 말초혈액도말에서 적혈구 내, 외에 존재하는 원충을 확인하는 것이 필수적이다. 그러나 말초혈액도말에서 원충을 확인하는 것은 경험과 시간을 요하므로 발열이 있는 환자에서는 항상 실시하는 전체혈구계산(CBC) 및 백혈구감별계산에서 이를 선별할 수 있다면 말라리아를 미처 의심하지 않은 환자에서도 진단이 늦어지는 일이 없고 매우 편리하리라고 사료된다. 최근 저자들은 Sysmex XE-2100 자동혈구분석기에서 혈소판감소증과 함께 가성호산구증가증을 보인 말라리아 환자 3예를 경험하였고, 자동혈구분석기에서 발견되는 hemozoin을 탐식한 백혈구로 인하여 나타나는 가성호산구증가증을 통하여 말라리아 원충을 확인하는 계기가 될 수 있다고 사료되어 문헌 고찰과 함께 보고하는 바이다.

Keywords

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