Journal of The Korean Ophthalmological Society (대한안과학회지)

The Korean Ophthalmological Society (대한안과학회)
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The Effect of Topical Pilocarpine on Basic Tear Secretion

필로카르핀 점안액이 기초눈물분비량에 미치는 영향

Kim, Sin-U;Lee, Jin-Hak
김신우;이진학

  • Published : 20060000
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Abstract

Purpose: To evaluate the effect of topical pilocarpine on basic tear secretion, using the Schirmer test. Methods: The Schirmer test was performed in 22 eyes of 11 healthy volunteers before instillation and at 10, 20, and 30 minutes after instillation of 1% pilocarpine and in 22 eyes of 12 healthy volunteers before instillation and at 10, 20, and 30 minutes after instillation of 2% pilocarpine. As for control group, the Schirmer test was performed in 22 eyes of 11 healthy volunteers by the same method except with normal saline. Results: The ratio of tear secretion was calculated by dividing the wet length of a Schirmer strip after instillation by the wet length before instillation for comparative analysis. In the control group, the mean ratio decreased with time to 0.78 at 10 minutes, 0.64 at 20 minutes, and 0.63 at 30 minutes after instillation of normal saline. In the 1% pilocarpine group, the mean ratio decreased with time, but there was no significant difference in comparison to the ratio of the control group. In the 2% pilocarpine group, the ratio increased significantly to 1.28 (p<0.001) at 10 minutes, 1.07 (p=0.002) at 20 minutes, and decreased to 0.63 (p=0.041) at 30 minutes after instillation. Conclusions: The basic tear secretion did not change significantly after instillation of 1% pilocarpine but increased significantly at 10 minutes after instillation of 2% pilocarpine to the highest level observed, which was followed by a decrease in basic tear secretion.

목적 : pilocarpine 점안액이 기초눈물분비량에 미치는 영향을 쉬르머검사를 이용해 알아보고자 한다. 대상과 방법 : 건강한 지원자 11명 22안을 대상으로 1% pilocarpine을 점안 전, 점안 후 10, 20, 30분에 쉬르머검사를 시행하였고, 12명 22안을 대상으로 2% pilocarpine을 동일한 방법으로 시행하였다. 대조군으로 11명 22안을 대상으로 생리식염수를 동일한 방법으로 시행하였다. 결과 : 점안 후 측정값을 점안 전 측정값으로 나눈 증감비를 살펴보면, 대조군의 경우 생리식염수를 점안 후 10, 20, 30분의 증감비가 각각 0.78, 0.64, 0.63으로 시간이 지날수록 감소하였다. 1% pilocarpine 점안군의 경우도 감소하는 경향을 보였으며, 대조군에 비해 통계학적으로 유의한 차이는 없었다. 그러나 2% pilocarpine 점안군의 경우 점안 후 10, 20, 30분의 증감비는 각각 1.28 (p<0.001), 1.07 (p=0.002), 0.84 (p=0.041)로 대조군에 비해 통계학적으로 유의하게 증가하였다가 점차 감소하였다. 결론 : 1% pilocarpine 점안시에는 기초눈물분비량에 유의한 차이가 없었지만, 2% pilocarpine 점안시 10분 후에 기초눈물분비량이 최대로 증가하였고 이 후 시간이 지날수록 기초눈물분비에 미치는 영향은 점차 감소하였다

Keywords

References

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