Experimental and Molecular Medicine

Korean Society for Biochemistry and Molecular Biongy (생화학분자생물학회)
권호 표지

Analysis of the variations in IL-28RA gene and their association with allergic rhinitis

Chae, Su-Cheon;Park, Yeong-Ran;Li, Chun-Shi;Lee, Jae-Hun;Yang, Yun-Sik;Qinggao, Zhang;Kim, Gyeong-Seok;Jeong, Heon-Taek
채수천;박영란;;이재훈;양윤식;;김경석;정헌택

  • Published : 20060000
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Abstract

IL-28RA is one of the important candidate genes for complex trait of genetic diseases, but there is no published information of the genetic variation in this gene. We scanned the seven exons and their boundary introns sequence of IL-28RA including the promoter regions to analyze genetic variation sites, and identified eighteen single nucleotide polymor-phisms (SNPs) and two variation sites. We chose seven SNPs (g.-1193 A＞C, g.-30 C＞T, g.17654 C＞T, g.27798 A＞G, g.31265 C＞T, g.31911 C＞T and g.32349 G＞A) of them for large sample size genotyping, and assessed the association of genotype and allele frequencies of these SNPs between allergic rhinitis patients and non-allergic rhinitis controls. We also compared the genotype frequencies between Korean controls and Han Chinese control or Korean Chinese control. We investigated the frequencies of haplotype con-structed by these SNPs between allergic rhinitis patients and non-allergic rhinitis controls. Our results suggested that the g.32349 G＞A polymor-phism of IL-28RAsceptibility to allergic rhinitis (P= 0.032), but seems to have no relationship with serum total IgE levels. The haplotype frequencies by these SNPs also show significant association between controls and aller-gic rhinitis patients.

Keywords

References

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