References
- Dent P, Yacoub A, Contessa J, Caron R, Amorino G, Valerie K, et al. Stress and radiation-induced activation of multiple intracellular signaling pathways. Radiat Res. 2003;159:283- 300 https://doi.org/10.1667/0033-7587(2003)159[0283:SARIAO]2.0.CO;2
- Ma BB, Bristow RG, Kim J, Siu LL. Combine-modality treatment of solid tumors using radiotherapy and molecular targeted agents. J Clin Oncol. 2003;21:2760-76 https://doi.org/10.1200/JCO.2003.10.044
-
Roche S, Koegl M, Courtneidge SA. The phosphatidylinositol 3-kinase
$\alpha$ is required for DNA synthesis induced by some, but not all, growth factors. Proc Natl Acad Sci USA. 1994;91: 9185-9 - Philpott KL, McCarthy MJ, Klippel A, Rubin LL. Activated phosphatidylinositol 3-kinase and Akt kinase promote survival of superior cervical neurons. J Cell Biol. 1997;139:809-15 https://doi.org/10.1083/jcb.139.3.809
- Davidson HW. Wortmannin causes mistargeting of procathepsin D. Evidence for the involvement of a phosphatidylinositol 3-kinase in vesicular transport to lysosomes. J Cell Biol. 1995; 130:797-805 https://doi.org/10.1083/jcb.130.4.797
- Leevers SJ, Vanhaesebroeck B, Waterfield MD. Signalling through phosphoinositide 3-kinases: the lipids take centre stage. Curr Opin Cell Biol. 1999;11:219-25 https://doi.org/10.1016/S0955-0674(99)80029-5
- Arbeit JM, Howley PM, Hanahan D. Chronic estrogen-induced cervical and vaginal squamous carcinogenesis in human papillomavirus type 16 transgenic mice. Proc Natl Acad Sci USA. 1996;93:2930-5 https://doi.org/10.1073/pnas.93.7.2930
- Cummings JH. Short-chain fatty acids in the human colon. Gut. 1981;22:763-79 https://doi.org/10.1136/gut.22.9.763
- Finzer P, Kuntzen C, Soto U, zur Hausen H, Rosl F. Inhibitors of histone deacetylase arrest cell cycle and induce apoptosis in cervical carcinoma cells circumventing human papillomavirus oncogene expression. Oncogene. 2001;20:4768-76 https://doi.org/10.1038/sj.onc.1204652
- Finzer P, Ventz R, Kuntzen C, Seibert N, Soto U, Rosl F. Growth arrest of HPV-positive cells after histone deacetylase inhibition is dependent of E6/E7 oncogene expression. Virology. 2002;304:265-73 https://doi.org/10.1006/viro.2002.1667
- Mandal M, Kumar R. Bcl-2 expression regulates sodium butyrate- induced apoptosis in human MCF-7 breast cancer cells. Cell Growth Differ. 1996;7:311-8
- Coradini D, Pellizzaro C, Marimpietri D, Abolafio G, Daidone MG. Sodium butyrate modulates cell cycle-related proteins in HT29 human colonic adenocarcinoma cells. Cell Prolif. 2000; 33:139-46 https://doi.org/10.1046/j.1365-2184.2000.00173.x
- Newmark HL, Young CW. Butyrate and phenylacetate as differentiating agents: practical problems and opportunities. J Cell Biochem. 1995;22(suppl):247-53
- Alonio LV, Picconi MA, Dalbert D, Mural J, Bartt O, Bazan G, et al. Ha-ras oncogene mutation associated to progression of papillomavirus induced lesions of uterine cervix. J Clin Virol. 2003;27:263-9 https://doi.org/10.1016/S1386-6532(02)00181-6
- Vanhaesebroeck B, Leevers SJ, Ahmadi K, Timms J, Katso R, Driscoll PC, et al. Synthesis and function of 3-phosphorylated inositol lipids. Annu Rev Biochem. 2001;70:535-602 https://doi.org/10.1146/annurev.biochem.70.1.535
-
Benistant C, Chapuis H, Roche S. A specific function for phosphatidylinositol 3-kinase
$\alpha$ (p85$\alpha$ -p110$\alpha$ ) in cell survival and for phosphatidylinositol 3-kinase$\beta$ (p85$\alpha$ -p110$\beta$ ) in de novo DNA synthesis of human colon carcinoma cells. Oncogene. 2000;19:5083-90 https://doi.org/10.1038/sj.onc.1203871 - Kermorgant S, Aparicio T, Dessirier V, Lewin MJ, Lehy T. Hepatocyte growth factor induces colonic cancer cell invasiveness via enhanced motility and protease overproduction. Evidence for PI3 kinase and PKC involvement. Carcinogenesis. 2001;22:1035-42 https://doi.org/10.1093/carcin/22.7.1035
- Ma YY, Wei SJ, Lin YC, Lung JC, Chang TC, Whang-Peng J, et al. PIK3CA as an oncogene in cervical cancer. Oncogene. 2000;25:2739-44
- Janson W, Brandner G, Siegel J. Butyrate modulates DNAdamage- induced p53 response by induction of p53-independent differentation and apoptosis. Oncogene. 1997;15:1395-406 https://doi.org/10.1038/sj.onc.1201304
- Yih LH, Lee TC. Arsenite induces p53 accumulation through an ATM-dependent pathway in human fibroblasts. Cancer Res. 2000;60:6346-52
- Wymann MP, Bulgarelli-Leva G, Zvelebil MJ, Pirola L, Vanhaesebroeck B, Waterfield MD, et al. Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys- 802, a residue involved in the phosphate transfer reaction. Mol Cell Bio. 1996;16:1722-33 https://doi.org/10.1128/MCB.16.4.1722
- Kennedy SG, Wagner AJ, Conzen SD, Jordan J, Bellacosa A, Tsichlis PN, et al. The PI 3-kinase/Akt signaling pathway delivers an antiapoptotic signal. Genes Dev. 1997;11:701-13 https://doi.org/10.1101/gad.11.6.701
- Boulton S, Kyle S, Yalcintepe L, Durkacz BW. Wortmannin is a potent inhibitor of DNA double strand break but not single strand break repair in Chinese hamster ovary cells. Carcinogenesis. 1996;17:2285-90 https://doi.org/10.1093/carcin/17.11.2285