Experimental and Molecular Medicine

Korean Society for Biochemistry and Molecular Biongy (생화학분자생물학회)
권호 표지

Tanshinone IIA inhibits osteoclast differentiation through down-regulation of c-Fos and NFATc1

Gwak, Han-Bok;Yang, Da-Eum;Ha, Hyeon-Il;Lee, Jong-Ho;Kim, Ha-Nui;U, Eun-Ran;Lee, Seung-Bok;Kim, Hong-Hui;Lee, Jang-Hui
곽한복;양다음;하현일;이종호;김하늬;우은란;이승복;김홍희;이장희

  • Published : 20060000
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Abstract

Bone is a dynamic tissue that is regulated by the activity of bone-resorbing osteoclasts and bone- forming osteoblasts. Excessive osteoclast forma-rheumatoid arthritis. Natural substances may be useful as therapeutic drugs to prevent many di-seases in humans because they avoid the many side effects of treatment with chemical compounds. Here we show that tanshinone IIA isolated from Salvia miltiorrhiza Bunge inhibits the receptor activator of NF-κB ligand (RANKL)-mediated osteoclast differen-tiation of osteoclast precursors. Tanshinone IIA suppressed the expression levels of c-Fos and NFATc1 induced by RANKL. However, retrovirus- mediated overexpression of c-Fos induced the ex-pression of NFATc1 despite the presence of tans-hinone IIA and reversed the inhibitory effect of tanshinone IIA on osteoclast differentiation. Also, NFATc1 retrovirus led to osteoclast diferentiation in the presence of tanshinone IIA. Our results suggest that tanshinone IIA may have a role as a therapeutic drug in the treatment of bone disease such as osteoporosis.

Keywords

References

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