Annals of Occupational and Environmental Medicine

The Korean Society of Occupational & Environmental Medicine (대한직업환경의학회)
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Effect of Sodium Benzoate on Change of Urinary Hippuric Acid and Methyl Hippuric Acid among Workers Coexposed to Toluene and Xylene

톨루엔 및 크실렌 노출 근로자에서 안식향산나트륨 섭취에 따른 요중 대사산물 농도의 시간적 변화

정최경희;김형수;고상백;이건세;장성훈;박수경;오원기

  • Published : 20060900
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Abstract

Objectives: This study was performed to investigate the effect of drink containing sodium benzoate on the change of urinary hippuric acid (UHA) and methyl hippuric acid(UMHA) excretion among workers coexposed to low toluene and xylene. Methods: Study subjects were 55 male shipbuilders who were divided into 3 groups; nonexposed group (n=10, who were not exposed to organic solvent and had drunk sodium benzoate), exposed A group (n=24, who were coexposed to toluene and xylene, and had drunk sodium benzoate), and exposed B group (n=21, who were coexposed to toluene and xylene, and had not drunk sodium benzoate). The study methodology consisted of questionnaire survey, urinary analysis for metabolites of toluene and xylene before and after drinking with or without sodium benzoate, and personal air sampling of toluene and xylene. Results: Before drinking, there was no significant difference in UHA or UMHA between the exposed A and B groups. After 1.5 hour of drinking, UHA of the exposed A group was significantly higher than that of the exposed B group. After 3 hours, however, UHA of the exposed A group was decreased to the level of the exposed B group, regardless of the ambient toluene level. UMHA exhibited no significant difference between the exposed A and B groups regardless of time and ambient toluene level. The regression model showed that drinking of sodium benzoate was positively correlated with UHA after 1.5 hours of drinking, but not after 3 hours. In addition, sodium benzoate didn’t affect UMHA. Conclusions: This study showed that sodium benzoate initially increased UHA temporally but that its effect disappeared after 3 hours. In the medical examination of toluene exposure workers, the ingestion of drink containing sodium benzoate should be forbidden during the 3 hours prior to urinary sampling.

목적: 저농도의 톨루엔과 크실렌에 동시 노출되는 근로자를 대상으로 안식향산나트륨 함유 음료 섭취가 요중 마뇨산 및 메틸마뇨산 배설 농도의 시간에 따른 변화에 미치는 영향을 파악하고자 하였다. 방법: 모 조선업체에 근무하는 근로자 중 사무직 남자 근로자 10명을 비노출군으로, 톨루엔과 크실렌에 동시에 노출되는 도장작업 남자 근로자 45명을 노출군으로 하였다. 노출군에 속하는 근로자들은 두 군으로 나누어 한 군(24명)은 안식향산나트륨 음료 섭취군(이하 노출A군)으로, 다른 한 군(21명)은 안식향산나트륨 비함유 음료 섭취군(이하 노출B군)으로 하였다. 2003년 10월 경 설문 조사와 함께 개인별로 기중 톨루엔과 크실렌 농도 및 요 중 대사산물을 측정하였다. 요중 대사산물 측정은 총 3회 하였으며, 첫 번째는 음료 섭취 전(작업시작 5시간 후)에, 두 번째는 음료 섭취 후 1.5시간에, 세 번째는 음료 섭취 후 3시간에 이루어졌다. 결과: 요중 마뇨산과 메틸마뇨산 농도에 공기 중 톨루엔 및 크실렌 노출수준과 안식향산나트륨 함유 음료 섭취가 시간에 따라 영향을 미치는지 알아보기 위한 다변량분석 결과, 음료 섭취 후 1.5시간에는 공기 중 톨루엔 농도와 안식향산나트륨 함유 음료 섭취 모두 유의한 영향을 미쳤고, 음료 섭취 후 3시간에는 공기 중 톨루엔 농도만이 유의한 영향을 미쳤다. 요중 메틸마뇨산 농도에는 음료 섭취 후 3시간(근무시작 8시간 후)에는 기중 크실렌 농도가 유의한 영향을 미쳤으나, 안식향산나트륨 함유 음료 섭취 여부는 유의한 영향을 미치지 못하였다. 결론: 본 연구를 통해 저농도 톨루엔 및 크실렌 노출 근로자들이 안식향산나트륨 함유 음료를 섭취하는 경우 요중 마뇨산 배설이 일시적으로 증가하며, 3시간 후에는 그 효과가 사라지는 것을 확인하였다. 따라서 톨루엔에 노출되는 근로자들에 대해서는 저농도에서도 특수건강진단 시 요중 마뇨산 농도를 측정하기 최소 3시간 이전부터는 안식향산나트륨이 함유된 식품을 섭취하지 않도록 주의해야 할 것이다.

Keywords

References

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