Obstetrics & gynecology science

Korean Society of Obstetrics and Gynecology (대한산부인과학회)
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Squamous cell carcinoma arising from mature cystic teratoma of the ovary: A clinicopathologic analysis

난소의 성숙낭성기형종에서 기원한 편평상피세포암의 임상병리학적 고찰

Kim, Min-Kyoung;Nam, Eun-Ji;Kim, Jae-Wook;Kim, Young-Tae;Kim, Jae Hoon;Kim, Sang-Wun;Yoon, Bo-Sung;Kim, Hye-Yeon;Kwak, Dong-Wook;Kim, Sung-Hoon
김민경;남은지;김재욱;김영태;김재훈;김상운;윤보성;김혜연;곽동욱;김성훈

  • Published : 20060700
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Abstract

Objective: The aim of this study was to evaluate clinicopathologic characteristics of squamous cell carcinoma arising from ovarian mature cystic teratoma and to determine whether SCC Ag and CA 125 are useful serum markers for diagnosing this tumor. Methods: From January 1990 to December 2005, 1266 patients diagnosed with ovarian mature cystic teratoma were reviewed. Of the 1266 patients, 8 patients which had squamous cell carcinoma arising from mature cystic teratoma were evaluated in this study. A retrospective analysis of clinicopathologic characteristics and disease-free survival rate was performed. Results: The incidence of squamous cell carcinoma arising from ovarian mature cystic teratoma was 0.7% (8/1266). The mean age of the patients was 47.3 years (range, 32-72 years). Five patients (62.5%) had clinical FIGO stage I disease and three patients (37.5%) had stage III disease. The mean tumor diameter was 13.3 cm. The mean SCC Ag level was 0.3 ng/mL which was normal and the mean CA 125 was slightly increased to 68.5 U/mL. The mean disease free survival was 58.4 months and 2-year disease-free survival was 62.5% (5/8). Out of 8 patients, one patient died and one out of 7 patients who survived had recurrence. Age, clinical FIGO stage, grade, residual tumor, postoperative treatment were not significant prognostic factor for disease- free survival. Conclusion: The incidence of squamous cell carcinoma arising from ovarian mature cystic teratoma in our institute was lower and survival rate was relatively higher compared to previous studies. SCC Ag and CA 125 were not helpful tumor markers in diagnosing squamous cell carcinoma arising from ovarian mature cystic teratoma. Age, grade, residual tumor, postoperative treatment were not significant prognostic factor for disease-free survival.

목적: 난소의 성숙낭성기형종에서 기원한 편평상피세포암은 매우 드문 악성종양으로 아직 보고가 된 바가 많지 않다. 본 연구는 이러한 희귀 종양의 임상병리학적 특성 및 무병 생존율과 종양표지자의 유용성에 대하여 고찰하고자 한다. 연구 방법: 1990년 1월부터 2005년 12월까지 본원을 내원하여 수술시행 후 조직학적으로 난소의 성숙낭성기형종을 진단받은 1,266명의 환자들 중 난소의 성숙낭성기형종에서 기원한 편평상피세포암으로 진단된 8명의 환자를 대상으로 하였다. 이들의 임상병리학적 특성, 무병 생존율 및 종양표지자 등을 후향적 방법으로 고찰하였다. 결과: 난소의 성숙낭성기형종에서 발생한 편평상피세포암의 빈도는 0.7%이었고 평균 발병연령은 47.3세 (32-72세)였다. Clinical FIGO stage는 I기가 5명 (62.5%)으로 가장 많았고, III기가 3명 (37.5%)이었으며 평균 종양의 직경은 13.3 cm이었다. 평균 SCC Ag의 수치는 0.3 ng/mL로 모두 정상범위였고 CA 125는 68.5 U/mL로 약간 증가되어 있었다. 평균 무병 생존기간은 58.4개월이었으며 2년 무병 생존율은 62.5%였다. 8명 중 1명은 사망하였고 생존한 7명 중 1명은 재발한 상태였다. 환자의 나이, clinical FIGO stage, 조직학적 분화도, 잔류종양의 크기, 수술 후 추가적 치료여부에 따른 무병 생존율에 차이가 없어 예후인자로 통계학적 의미는 없었다. 결론: 본 기관에서의 난소의 성숙낭성기형종에서 발생한 편평상피세포암의 빈도는 비교적 낮고, 전체 무병 생존율이 양호한 것으로 판단된다. SCC Ag과 CA 125는 난소의 성숙낭성기형종에서 발생한 편평상피세포암의 진단에 도움을 주지 못하며 환자의 나이, clinical FIGO stage, 조직학적 분화도, 잔류종양의 크기, 수술 후 추가적 치료여부에 따른 무병 생존율에 차이가 없어 예후인자로 통계학적인 의미는 없었다.

Keywords

References

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