Laboraroty Animal Research

Korean Association for Laboratory Animal Science (한국실험동물학회)
권호 표지

Antidiabetic Effects of Calcium Ion $Water^{\circledR}$ in Neonatal Streptozotocin-Induced Noninsulin-Dependent Diabetes Mellitus in Rats

Lee, Mi-Ree;Hong, Jin-Won;No, Young-Soo;Jeong, Sung-Guk;Cho, Ji-Young;Choi, Soo-Nyun;Choi, Sun-Young;Kim, Yoo-Ri;Song, Jae-Chan;Kim, Kil-Soo

  • Published : 20060000
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Abstract

The antidiabetic effect of Calcium Ion $Water^{\circledR}$ ($CIW^{\circledR}$) was investigated in neonatal streptozotocin (90 ㎎/㎏, i.p.)-induced noninsulin-dependent diabetes mellitus (NIDDM) in Sprague Dawley rats. The rats were divided into three groups: normal control, NIDDM control, and NIDDM + $CIW^{\circledR}$. $CIW^{\circledR}$ treatment for 8 weeks resulted in a significant decrease in the concentration of blood glucose and an increase in the level of serum insulin in NIDDM rats. The blood glucose and serum insulin levels were significantly lower and higher, respectively, than those of the NIDDM control group after 4 weeks of $CIW^{\circledR}$ treatment. The changes of body weight in all experimental groups were not different among normal control, NIDDM control, and NIDDM + $CIW^{\circledR}$. In conclusion, these results indicate that $CIW^{\circledR}$ can be used as an antidiabetic functional drink because it increases insulin level in blood and concomitantly decreases blood glucose level.

Keywords

References

  1. American Diabetes Association (2001) Report of the expert committee on the diagnosis and lassifieation of diabetes millitus. Diabetes Care 24 (Suppl. I), 5-20 https://doi.org/10.2337/diacare.24.1.5
  2. Cavaghan, M.K., Khrmann, D.A. and Polonsky, K.S. (2000) Interactions between insulin resistance and insulin secretion in the development of glucose intolerance. J. Clin. Invest. 106, 329-333 https://doi.org/10.1172/JCI10761
  3. Chang, K.C., Tseng, C.D., Chou, T.F., Cho, Y.L., Chi, T.C., Su M.J. and Tseng, Y.Z. (2006) Arterial stiffening and cardiac hypertrophy in a new rat model of type 2 diabetes. Eur. J. Clin. Invest. 36, 1-7
  4. Hanaoka, K. (2001) Antioxidant effects of reduced water produced by electrolysis of sodium chloride solutions. J. Appl. Electrochem. 31, 1307-1313 https://doi.org/10.1023/A:1013825009701
  5. Hayden, J.M. and Reaven, P.D. (2000) Cardiovascular disease n diabetes mellitus type 2: a potential role for novel cardiovascular risk factors. Curr. Opin. Lipidol. 11, 519-28 https://doi.org/10.1097/00041433-200010000-00010
  6. Jin, D., Ryu, S.H., Kim, H.W., Yang, E.J., Lim, S.J., Ryang, Y.S., Chung, C.H., Park, S.K. and Lee, K.J. (2006) Anti-diabetic effect of Alkaline-Reduced Water on OLETF Rats. Biosci. Biotechnol. Biochem. 70(1), 31-37 https://doi.org/10.1271/bbb.70.31
  7. Junod, A., Lambert, A.E., Orci, L., Pictet, R., Gonet, A.E. and Renord, A.E. (1967) Studies of the diabetogenic action of streptozotocin. Proc. Soc. Exp. Biol. Med. 126, 210-216
  8. Kahn, S.E. (2001) The importance of -cell failure in the development and progression of type 2 diabetes. J. Clin. Endoerinol. 86,4047-4058 https://doi.org/10.1210/jc.86.9.4047
  9. Kenny, S.J., Aubert, R.E. and Geiss, L.S. (1995) Diabetes in America, 2nd ed., pp. 47-67, Diane Publishing Co., Bethesda
  10. Landau, B.R., Wahren, J., Chandramouli, V, Schumann, W.C., Ekberg, K. and Kalhan, S.C. (1996) Contributions of gluconeogenesis to glucose production in the fasted state. J. Clin. Invest. 98, 378-385 https://doi.org/10.1172/JCI118803
  11. Portha, B., Picon, L. and Rosselin, G. (1979) Chemical diabetes in the adult rat as the spontaneous evolution of neonatal diabetes. Diabetologia 17, 371-377 https://doi.org/10.1007/BF01236272
  12. Reaven, G.M. and Laws, A. (1994) Insulin resistance, compensatory hyperinsulinaemia, and coronary heart disease. Diabetologia 37, 948-52 https://doi.org/10.1007/BF00400953
  13. Shirahata, S., Kabayama, S., Nakano, M., Miura, T., Kusumoto, K., Gotoh, M., Hayashi, H., Otsubo, K., Morisawa, S. and Katakura, Y. (1997) Electrolyzed-reduced water scavenges active oxygen species and protects DNA from oxidative damage. Biochem. Biophys. Res. Comm. 234, 269-274 https://doi.org/10.1006/bbrc.1997.6622
  14. Steinberg, H.O., Chaker, H., Learning, R., Johnson, A., Brechtel, G. and Baron, A.D. (1996) Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance. J. Clin. Invest. 97, 2601-10 https://doi.org/10.1172/JCI118709
  15. Treadway, J.L., Mendys, P. and Hoover, D.J. (2001) Glycogen phosphorylase inhibitors for treatment of type 2 diabetes mellitus. Expert. Opin. Invest. Drugs 10, 439-454 https://doi.org/10.1517/13543784.10.3.439
  16. Watanabe, T. (1995) Effect of alkaline ionized water on reproduction in gestational and lactational rats. J. Toxicol. Sci. 20, 135-142 https://doi.org/10.2131/jts.20.135
  17. Weyer, C., Bogardus, C., Mott, D.M. and Pratley, R.E. (1999) The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J. Clin. Invest. 104, 787-794 https://doi.org/10.1172/JCI7231