The Korean Journal of Gastroenterology (대한소화기학회지)

The Korean Society of Gastroenterology (대한소화기학회)
권호 표지

Mechanism of Actions and Clinical Applications of Proton Pump Inhibitors

Proton Pump Inhibitors의 작용기전과 사용법

Seol, Sang-Yeong
설상영

  • Published : 20060000
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Abstract

Proton pump inhibitors (PPIs) are widely used in clinical practice from early 1990s for the treatment of acid- related diseases. PPIs are superior to histamine2-receptor antagonists or anticholinergic agents. These drugs have proven to be effective, safe and well-tolerated during the past two decades. This brief review presents the pharmacodynamics and pharmacokinetics of PPIs and presents clincal applications of the drugs in acid-related diseases.

Keywords

References

  1. Maton PN. Omeprazole. N Engl J Med 1991;324:965-975
  2. Shull GE, Lingrel JB. Molecular cloning of the rat stomach $H^{+}$+$K^{+}$ -ATPase. J Biol Chem 1986;261:16788-16791
  3. Maeda M, Ishizaki J, Eutai M. Human gastric $H^{+}$+$K^{+}$-ATPase gene. Similarity to $Na^{+}$+$K^{+}$-ATPase genes in exon/ intron organization but difference in control region. J Biol Chem 1990;265:9027-9032
  4. Sachs G. The continuing development of gastric acid pump inhibitors. Aliment Pharmacol Ther 1993;7(suppl):4S-12S
  5. Lind T, Cederberg C, Ekenved G. Effect of omeprazole-a gastric proton pump inhibitor-on pentagastrin stimulated acid secretion in man. Gut 1983;24:170-176
  6. Peghini PL, Katz PO, Castell DO. Nocturnal recovery of gastric acid secretion with twice-daily dosing of proton pump inhibitors. Am J Gastroenterol 1998;93:763-767
  7. Katsube T, Adachi K, Kawamura A, et al. Helicobacter pylori infection influences nocturnal gastric acid breakthrough. Aliment Pharmacol Ther 2000;14:1049-1056
  8. Furuta T, Shirai N, Watanabe F, et al. Effect of cytochrome P4502C19 genotypic differences on cure rates for gastroesophageal reflux disease by lansoprazole. Clin Pharmacol Ther 2002;72:453-460
  9. Burget D, Chiverton S, Hunt R. Is there an optimal degree of acid suppression for healing of duodenal ulcers? Gastroenterology 1990;99:345-351
  10. Green F, Kaplan M, Curtis L. Effect of acid and pepsin on blood coagulation and platelet aggregation. Gastroenterology 1978;74:38-43
  11. Keane WF, Swan SK, Grimes I, Humphries TJ. Rabeprazole: pharmacokinetics and tolerability in patients with stable, end stage renal failure. J Clin Pharmacol 1999;39:927-933
  12. Chassany O, Bergmann J, Simoneau G, et al. The comparative effects of single intravenous doses of cimetidine, ranitidine, famotidine, and omeprazole on intragastric pH. Current Therapeutic Research 1996;57:159-167
  13. Abe Y, Inamori M, Togawa J, et al. The comparative effects of single intravenous doses of omeprazole and famotidine on intragastric pH. J Gastroenterol 2004;39:21-25