Korean Journal of Anesthesiology

The Korean Society of Anesthesiologists (대한마취통증의학회)
권호 표지

Effects of Vancomycin on the Neuromuscular Blockade of Vecuronium, Rocuronium and Atracurium in the Rat Phrenic Nerve-Hemidiaphragm Preparation

흰쥐 횡격막 신경근 표본에서 Vancomycin이 비탈분극성 근이완제의 신경근 차단에 미치는 영향

Kim, Soon-Im;Han, Chang-Yoon;Jung, Ho-Soon;Lee, Jeong-Seok;Ok, Si-Young;Kim, Sun-Chong
김순임;한창윤;정호순;이정석;옥시영;김선종

  • Published : 20061200
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Abstract

Background: Vancomycin is frequently used as a prophylactic antibiotic in patients undergoing cardiac and orthopedic surgical procedures. However, the interactions of vancomycin with non-depolarizing muscle relaxant have not yet been reported on. Therefore, we studied the effects of vancomycin on the neuromuscular block of vecuronium, rocuronium and atracurium in vitro. Methods: Square wave, 0.1 Hz supramaximal stimuli were applied to the phrenic nerve-hemidiaphragm preparation of the rat and the twitch height response was recorded. We measured cumulative concentration response curves of vecuronium, rocuronium or atracurium, respectively, and also those of the rats that were pretreated with vancomycin (20${\mu}g$/ml). The $EC_{50}$ and $EC_{95}$ of these muscle relaxants alone and those of the rats pretreated with vancomycin were calculated with using an inhibitory sigmoid Emax model. Results: Vancomycin alone did not depress the twitch height. The pretreated vancomycin (20${\mu}g$/ml) did not affect the $EC_{50}$ and $EC_{95}$ of vecuronium or rocuronium, but it significantly reduced the $EC_{50}$ and $EC_{95}$ of atracurium (P ＜ 0.05). Conclusions: Vancomycin itself does not have neuromuscular blocking properties. Vancomycin does not affect the neuromuscular blockade induced by vecuronium or rocuronium, but it significantly enhances the neuromuscular blockade induced by atracurium.

Keywords

References

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