The Journal of Korean Obstetrics and Gynecology (대한한방부인과학회지)

The Society of Korean Medicine Obstetrics and Gynecology (대한한방부인과학회)
권호 표지

Administration Duration Dependent Effects of Epimedium Herb Extract Solution on the Reproductive Capacities in the Mice

음양곽(淫羊藿)의 수컷 생쥐 생식능력(生殖能力)에 대한 투약기간별(投藥期間別) 효과(效果)

  • Lee, Chang-Hoon (Dept. of Oriental Gynecology, College of Oriental Medicine, Kyung Hee University) ;
  • Cho, Jung-Hoon (Dept. of Oriental Gynecology, College of Oriental Medicine, Kyung Hee University) ;
  • Jang, Jun-Bock (Dept. of Oriental Gynecology, College of Oriental Medicine, Kyung Hee University) ;
  • Lee, Kyung-Sub (Dept. of Oriental Gynecology, College of Oriental Medicine, Kyung Hee University) ;
  • Choi, Jung-Eun (Dept. of Oriental Gynecology, College of Oriental Medicine, Kyung Hee University)
  • 이창훈 (경희대학교 한의과대학 부인과학교실) ;
  • 조정훈 (경희대학교 한의과대학 부인과학교실) ;
  • 장준복 (경희대학교 한의과대학 부인과학교실) ;
  • 이경섭 (경희대학교 한의과대학 부인과학교실) ;
  • 최정은 (경희대학교 한의과대학 부인과학교실)
  • Published : 2006.08.31
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Abstract

Purpose : This study was undertaken to evaluate the effects of the different administration duration of Epimedium Herb extract solution on the spermatogenic abilities such as concentration, motility and morphological normality of sperm from the testis and the activities of sperm hyaluronidase. Methods : We used the 2-month-old mice and administered the extract solution of Epimedium Herb 0.3 ml/g/day for 30, 60, 90 and 120 days. The control group was administered the normal saline as the same way. We examined the number of total, motile and normal sperm from the cauda epididymis, the activities of sperm hyaluronidase. Also we observed changes of isolated testis before and after administration of Epimedium Herb extract solutions in the mice. And we compared the testicular tissue especially seminiferous tubules with the control and treated group by histochemical methods. Results : The significant differences were observed in the concentration of total sperm and normality of spermatozoa of the Epimedium Herb extract solution administered groups compared to the control group in 60, 90 and 120 days groups. The significant differences were observed the motility of the Epimedium Herb extract solution administered groups compared to the control group in 60 days group. In the histological analysis of the testicular tissues, the enlargement of testicular lobe diameter and apparent vasculogenesis between testicular lobes were observed in the Epimedium Herb extract solution administered groups compared to the control group, respectively. And the activity of hyaluronidase was significantly increased in the Epimedium Herb extract solution administered groups compared to the control group. Conclusion : This study shows that Epimedium Herb has the beneficial effect on the concentration, morphology and motility of sperm, the testicular tissues and the activities of sperm hyaluronidse in 60 days administration group. We can suggest that Epimedium Herb extract solution be useful for the treatment of male sexual dysfunction and infertility.

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