The Journal of Korean Obstetrics and Gynecology (대한한방부인과학회지)

The Society of Korean Medicine Obstetrics and Gynecology (대한한방부인과학회)
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Effects of Retention Enema Therapy Gamihongdeung-tang on Surgically Induced Endometriosis in Rats

가미홍등탕(加味紅藤湯) 직장 내 투여가 자궁내막증을 유발한 흰쥐에 미치는 영향

  • Lim, Eun-Mee (Dept. of Gynecology, College of Oriental Medicine, Kyungwon University) ;
  • Kwon, Ki-Rok (Dept. of Acupuncture and Moxibustion, College of Oriental Medicine, Sangji University) ;
  • Yi, Ji-Youn (Dept. of Gynecology, College of Oriental Medicine, Kyungwon University)
  • 임은미 (경원대학교 한의과대학 부인과학교실) ;
  • 권기록 (상지대학교 한의과대학 침구학교실) ;
  • 이지연 (경원대학교 한의과대학 부인과학교실)
  • Published : 2006.08.31
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Abstract

Purpose : To observe the effect of retention enema therapy Gamihongdeung-tang on experimentally induced endometriosis. Methods : Rats with surgically induced endometriosis were administered in Gamihongdeung-tang rectally. After treatment for 40 days, the serum concentrations of progesterone, estradiol, tumor necrosis factor-${\alpha}$(TNF-${\alpha}$),　interleukin(IL)-2,　IL-4, IL-6 and IL-10 were measured. Results : The size of the ectopic uterine implants in the treated group was much smaller than that in the control group. The concentration of estradiol was significantly lower in the experimental group than in the control group. The IL-4, IL-6 levels were significantly lower in the experimental groups than the control groups. TNF-${\alpha}$, IL-2 levels were lower and IL-10 level was higher in the experimental groups than in the control groups but the difference was not significent. The progesterone level was similar in the experimental and control group. Conclusion : These results indicate that Retention enema therapy with Gamihongdeung-tang reduces the size of ectopic uterine implants at the serosal wall and inhibits the growth of ectopic uterine implants. This suggests that retention enema therapy with Gamihongdeung-tang is an effective treatment for endometriosis.

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