Polymer(Korea) (폴리머)

The Polymer Society of Korea (한국고분자학회)
권호 표지

The Effects of Osmogant and Binder in Membrane on Nifedipine Release from Osmotic Granule

니페디핀의 삼투성 과립에서 삼투염과 반투막내의 결합제 종류가 약물방출에 미치는 영향

  • Jeong Sung-Chan (Department of Polymer Engineering, Pukyung University) ;
  • Cho Young-Ho (Department of Advanced Organic Materials Engineering, Chonbuk National University) ;
  • Kim Moon-Suk (NanoBiomaterials Laboratory, Korea Research of Chemical Technology) ;
  • Lee Bong (Department of Polymer Engineering, Pukyung University) ;
  • Khang Gil-Son (Department of Advanced Organic Materials Engineering, Chonbuk National University, NanoBiomaterials Laboratory, Korea Research of Chemical Technology) ;
  • Rhee John-M. (Department of Advanced Organic Materials Engineering, Chonbuk National University) ;
  • Lee Hai-Bang (Department of Advanced Organic Materials Engineering, Chonbuk National University, NanoBiomaterials Laboratory, Korea Research of Chemical Technology)
  • 정성찬 (부경대학교 고분자공학과) ;
  • 조영호 (전북대학교 유기신물질공학과) ;
  • 김문석 (한국화학연구원 나노생체재료연구팀) ;
  • 이봉 (부경대학교 고분자공학과) ;
  • 강길선 (전북대학교 유기신물질공학과, 한국화학연구원 나노생체재료연구팀) ;
  • 이종문 (전북대학교 유기신물질공학과) ;
  • 이해방 (전북대학교 유기신물질공학과, 한국화학연구원 나노생체재료연구팀)
  • Published : 2006.03.01
Download PDF
⟨ Previous Next ⟩

Abstract

To improve the type error of osmotic tablet which is one of the drug delivery system, osmotic granule could be manufactured by fluidized bed coating. It has drug layer containing different amount of osmogant and is coated with membrane including different types of binder. We confirmed that the morphology of osmotic granule was different at each coating step. The more mont of osmotic agent, the faster drug release was observed due to increasing the driving force for drug release from osmotic granule. And drug release from osmotic granule coated with membrane using different types of binder was differed by solubility of binders to water. The formation of pore in membrane was confirmed by SEM and DSC Membrane using water soluble binder released more amount of drug. From these results, we assured that difference of osmotic pressure between the inside and the outside of granule and porosity of membrane have an effect on drug release from osmotic granule.

약물전달 시스템 중의 하나인 삼투압정의 단점을 보완하기 위해 많은 장점을 가지는 유동층 코팅 기술을 이용하여 내부의 삼투염의 양과 반투막 내의 결합제의 종류가 다른 삼투압을 이용하는 과립을 제조하였다. 얻어진 과립은 코팅 단계에 따라 과립의 형태가 상이하였으며, 약물층에 포함된 삼투염의 양이 많을수록 많은 양의 약물을 방출하였다. 이는 과립의 내부와 외부의 삼투압 차이가 커져서 약물을 방출시키는 추진력이 증가하였기 때문으로 사료된다. 또한 반투막의 결합제 종류에 따른 약물의 방출은 결합제의 물에 대한 용해도에 따라 달라짐을 확인할 수 있었다. 반투막 내의 다공의 형성은 SEM과 DSC를 이용하여 확인하였으며, 물에 대한 용해도가 큰 결합제를 사용한 반투막이 더 많은 양의 약물을 방출함을 확인하였다. 이 실험을 통해 삼투압을 이용한 과립의 약물방출은 과립 내부와 외부의 삼투압 차이와 반투막의 다공도에 의해 영향을 받는다는 것을 확인하였다.

Keywords

References

  1. L. Perkins, C. Peer, and V. Fleming, 'Pumps/osmotic-alzet system', in Encyclopedia of Controlled Drug Delivery, E. Mathiowitz, Ed., Wiley, New York, U.S.A, Vol. 2, pp 900-906 (1999)
  2. J. Magruder, 'Pumps/osmotic-VITS veterinary implant', in Encyclopedia of Controlled Drug Delivery, E. Mathiowitz, Ed., Wiley, New York, U.S.A, Vol. 2, pp 906-909 (1999)
  3. J. C. Wright, C. L. Stevenson, and G. R. Stewart, 'Pumps/osmotic-DUROS osmotic implant for humans', in Encyclopedia of Controlled Drug Delivery, E. Mathiowitz, Ed., Wiley, New York, U.S.A, Vol. 2, pp 909-915 (1999)
  4. J. Wright, 'Pumps/osmotic-rumina! osmotic bolus', in Encyclopedia of Controlled Drug Delivery, E. Mathiowitz, Ed., Wiley, New York, U.S.A, Vol. 2, pp 915-920 (1999)
  5. F. Theeuwes, P. S. L. Wong, T. L. Burkoth, and D. A. Fox, 'Osmotic systems for colon-targeted drug delivery', in Colonic Drug Absorption and Metabolism, P. R. Bieck, Ed., Marcel Dekker, New York, U.S.A, pp 137-158 (1993)
  6. A. Amkraut, J. B. Eckenhoff, and K. Nichols, Adv. Drug Deliv. Rev., 4, 255 (1990) https://doi.org/10.1016/0169-409X(89)90021-5
  7. F. Theeuwes, J. Pharm. Sci., 64, 1987 (1975) https://doi.org/10.1002/jps.2600641218
  8. P. S. L. Wong, B. L. Barclay, J. C. Deters, and F. Theeuwes, U.S. Patent 4,765,989 (1986)
  9. F. Theeuwes, Pharm. Int., 5, 293 (1984)
  10. F. Theeuwes, Novel Drug Delivery Systems, ADIS Press, p. 157 (1981)
  11. H. Kage, R. Abe, R. Hattanda, T. Zhou, H. Ogura, and Y. Matsuno, Powder Technol., 130, 203 (2003) https://doi.org/10.1016/S0032-5910(02)00267-X
  12. P. B. Deast, Microencapsulation and Related Drug Processes, Marcel Dekker, New York, 1984
  13. L. Liu, G. Khang, J. M. Rhee, and H. B. Lee, Polymer(Korea), 7, 289 (1999)
  14. L. Liu, G. Khang, J. M. Rhee, and H. B. Lee, Biomater. Res., 3, 47 (1999)
  15. L. Liu, G. Khang, J. M. Rhee, and H. B. Lee, Bio-Med. Mater. Eng., 9, 297 (1999)
  16. L. Liu, G. Khang, J. M. Rhee, and H. B. Lee, J. Control. Rel., 67, 309 (2000) https://doi.org/10.1016/S0168-3659(00)00222-4
  17. L. Liu, J. Ku, G. Khang, B. Lee, J. M. Rhee, and H. B. Lee, J. Control. Rel., 68, 145 (2000) https://doi.org/10.1016/S0168-3659(00)00243-1
  18. G. Khang, J. Ku, B. Lee, and H. B. Lee, Biomater. Res., 4, 20 (2000)
  19. L. Lui, G. Khang, J. M. Rhee, and H. B. Lee, Acta Pharm. Sinica, 38, 620 (2003)
  20. L. Lui, Q. Xu, G. Khang, J. M. Rhee, and H. B. Lee, Acta Pharm. Sinica, 38, 966 (2003)
  21. K. Sudsakorn and R. Turton, Powder Technol., 110, 37 (2000) https://doi.org/10.1016/S0032-5910(99)00266-1
  22. H. Kage, R. Abe, R. Hattanda, T. Zhou, H. Ogura, and Y. Matsuno, Powder Technol., 130, 203 (2003) https://doi.org/10.1016/S0032-5910(02)00267-X
  23. M. Donbrow, Ed., Microencapsulation and Nsnoperticles in Medicine and Pharmacy, CRC Press, Boca Raton, FL, 1991
  24. H. Ho, C. Chen, and M. Sheu, J. Control Rel., 68, 433 (2000) https://doi.org/10.1016/S0168-3659(00)00281-9
  25. Y. Wang and M. A. Winnik, Macromol., 23, 4731 (1990) https://doi.org/10.1021/ma00223a038
  26. J. Siepmann, F. Lecomte, and R. Bodmeirer, J. Control. Rel., 60, 379 (1999) https://doi.org/10.1016/S0168-3659(99)00093-0
  27. S. C. Jeong, S. K. Chon, Y. H. Jo, M. S. Kim, B. Lee, G. Khang, and H. B. Lee, Polymer(Korea), 29, 288 (2005)
  28. P. Colombo, R. Bettimi, G. Massimo, P. L. Catellani, P. Santi, and N. A. Peppas, J. Pharm. Sci., 84, 991 (1995) https://doi.org/10.1002/jps.2600840816
  29. R. C. Rowe, Int. J. Pharm., 29, 37 (1986) https://doi.org/10.1016/0378-5173(86)90197-3
  30. A. Wade and P. J. Weller, Eds., Handbook of Pharmaceutical Exdpients, Am. Pharm. Assoc., Washington DC, 1994
  31. M. R. Harris, I. Ghebre-Sellassie, and R. U. Nesbitt, Pharm. Technol., 10, 102 (1986)
  32. M. M. Meier, L. A. Kanis, and V Soldi, Int. J. Pharm., 278, 99 (2004) https://doi.org/10.1016/j.ijpharm.2004.03.005
  33. H. S. A. Auda, T. A. Najjar, K. I. Al-Khamis, B. M. Al-Hadiya, N. M. Ghilzai, and N. F. Al-Fawzan, J. Pharm. Biomed. Anal., 22, 241 (2000) https://doi.org/10.1016/S0731-7085(99)00258-7
  34. I. Niopas and A. C. Dafrsios, J. Pharm. Biomed. Anal., 32, 1213 (2003) https://doi.org/10.1016/S0731-7085(03)00162-6