Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Inhibitory Activity of 6-O-Angeloylprenolin from Centipeda minima on Farnesyl Protein Transferase

  • Oh, Hyun-Mi (Korea Research Institute of Bioscience and Biotechnology, KIST) ;
  • Kwon, Byoung-Mog (Korea Research Institute of Bioscience and Biotechnology, KIST) ;
  • Baek, Nam-In (Graduate School of Biotechnology & Plant Metabolism Research Center, KyungHee University) ;
  • Kim, Sung-Hoon (Graduate School of East-West Medical Science, KyungHee University) ;
  • Lee, Jae-Hyeok (Department of Oriental Pharmaceutical development, Nambu University) ;
  • Eun, Jae-Soon (College of Pharmacy, Woosuk University) ;
  • Yang, Jae-Heon (College of Pharmacy, Woosuk University) ;
  • Kim, Dae-Keun (College of Pharmacy, Woosuk University)
  • Published : 2006.01.01
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Abstract

The methanolic extract of the aerial parts of Centipeda minima was found to show inhibitory activity on farnesyl protein transferase (FPTase). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of 6-O-angeloylprenolin, as an inhibitor on FPTase. This compound inhibited FPTase activity in a dose-dependent manner, and the $IC_{50}$ value of 6-O-angeloylprenolin was 18.8 ${\mu}M$.

Keywords

References

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