YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

The Antidepressant Effects of Cirsium japonicum in ICR Mice

ICR생쥐에서 엉겅퀴 잎 추출물의 항우울 효과

  • Park, Hyung-Keun (Uimyung Research Institute for Neuroscience, Sahmyook University) ;
  • Yoon, Seo-Young (Uimyung Research Institute for Neuroscience, Sahmyook University) ;
  • Choi, Jong-Hyun (Uimyung Research Institute for Neuroscience, Sahmyook University) ;
  • Ko, Hong-Sook (Uimyung Research Institute for Neuroscience, Sahmyook University) ;
  • Suh, Yeon-Won (Department of Makeup & Coordination, Daewon Science College) ;
  • Lee, Yong-Soo (College of Pharmacy and Duksung Women's University) ;
  • Kim, Gun-Hee (Plant Resources Research Institute, Duksung Women's University) ;
  • Chung, Mi-Sook (Plant Resources Research Institute, Duksung Women's University) ;
  • Cheong, Jae-Hoon (Uimyung Research Institute for Neuroscience, Sahmyook University)
  • 박형근 (삼육대학교 의명신경과학연구소) ;
  • 윤서영 (삼육대학교 의명신경과학연구소) ;
  • 최종현 (삼육대학교 의명신경과학연구소) ;
  • 고홍숙 (삼육대학교 의명신경과학연구소) ;
  • 서연원 (대원과학대학 메이크업코디과) ;
  • 이용수 (덕성여자대학교 약학대학) ;
  • 김건희 (덕성여자대학교 식물자원연구소) ;
  • 정미숙 (덕성여자대학교 식물자원연구소) ;
  • 정재훈 (삼육대학교 의명신경과학연구소)
  • Published : 2006.12.31
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Abstract

The antidepressant effects of Cirsium japonicum compositae was investigated using open field test and forced swimming test. Total extract of Cirsium japonicum (CJ) was orally administered at dose of 20, 100, 300, 500 mg/kg bodyweight. Supplementation of CJ increased dose-dependently movement, rearing frequency and total turn angle in the center area of open field in mice. Treatment of Cirsium japonicum's extract (300 mg/kg, CJ) decreased immobile duration and increased mobile and strong mobile duration significantly; and it is comparable to that of imipramine and fluoxetine. These results indicate that CJ has antidepressant effect. Treatment of CJ did not induced any impairment in motor coordination and myorelaxation. These results indicate that the constituents or its complex of Cirsium japonicum could be a candidate of new antidepressant drug.

Keywords

References

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