The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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Effects of High Frequency Herbal Medication Administrations on the Liver Functions in Rats - Focusing on Sipjeondaebo-tang, Yukmaijihwang-tang, Bojungikgi-tang, and Ojeoksan -

다용 한약처방 투여가 흰쥐의 간기능에 미치는 영향 - 십전대보탕, 육미지황탕, 보중익기탕 및 오적산을 중심으로 -

  • Han Yong-Joo (Dept. of Preventive Medicine, College of Oriental Medicine, Sangji University) ;
  • Lee Sun-Dong (Dept. of Preventive Medicine, College of Oriental Medicine, Sangji University) ;
  • Choi Jong-Hwan (Dept. of Biochemistry, College of Medicine, Wonju Yonsei University) ;
  • Park Jong-Goo (Dept. of Preventive Medicine, College of Medicine, Wonju Yonsei University) ;
  • Jang In-Soo (Dept. of Internal Medicine. College of Korean Medicine, Woosuk University) ;
  • Park Hae-Mo (Dept. of Preventive Medicine, College of Oriental Medicine, Sangji University)
  • 한용주 (상지대 한의과대학 예방의학교실) ;
  • 이선동 (상지대 한의과대학 예방의학교실) ;
  • 최종환 (연세대 원주의과대학 생화학교실) ;
  • 박종구 (연세대 원주의과대학 예방의학교실) ;
  • 장인수 (우석대 한의과대학 심계내과학 교실) ;
  • 박해모 (상지대 한의과대학 예방의학교실)
  • Published : 2006.03.01
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Abstract

Background : Traditional herbal medicine is used extensively among the Korean populations, and other Asian countries employ similar therapies as well. In recent years, extensive focus was laid on adulteration of the herbal medicine with liver damage. The use of herbal preparations as remedies for various medical conditions has continuously increased in Korea. Large proportions of Korean patients use herbal medicinal products, folk remedies, and health food. However, studies on the safety of herbal products are conducted on a less than sufficient basis even in the countries like Korea where herbal medicine is being used extensively. Some of the reports on the safety of herbs were done by the doctors of western medicine but lack of knowledge and misclassification led to misunderstandings. Objectives : This study aims to verify the evidences on safety of frequently used 4 herbal medications (Sipjeondaebo-tang, Bojungikgi-tang, Ohjeok-San, Yukmaijihwang-tang) in the lab animal model. Methods : Sprague-Dawley rats was treated by 4 herbal medications during 31 days. After 1 month, we checked body weight, liver weight, and serum enzyme associated with liver function. Results : There is no significant difference in body weight and liver weight after 1 month of administrations. In all experimental groups, no abnormal findings was observed in histotogical research and lab liver Functions test(AST, ALT etc). Conclusions : These four herbal medications, frequently used in oriental medicine clinics and hospitals, are safe from hepatoxic events in the lab animal model.

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