The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Effect of A Combined Prescription on Liver Injury of Rats by $CCl_4$

사역산합평위산가인진택사방(四逆散合平胃散加茵蔯澤瀉方)이 $CCl_4$에 의한 흰쥐의 간(肝) 손상에 미치는 영향

  • Kim, Hyung-Woo (Dept. of Herbology, College of Korean Medicine, Dongshin University) ;
  • Kim, Sung-Wook (Dept. of Acupuncture-Moxibustion, College of Korean Medicine, Dongshin University) ;
  • Yun, Yeo-Choong (Dept. of Acupuncture-Moxibustion, College of Korean Medicine, Dongshin University) ;
  • Cho, Su-In (Dept. of Herbology, College of Korean Medicine, Dongshin University)
  • 김형우 (동신대학교 한의과대학 본초학교실) ;
  • 김성욱 (동신대학교 한의과대학 침구학교실) ;
  • 윤여충 (동신대학교 한의과대학 침구학교실) ;
  • 조수인 (동신대학교 한의과대학 본초학교실)
  • Published : 2006.09.30
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Abstract

Objectives : This study was undertaken to determine if a combined(SPe) has a protective effect against functional failure induced by $CCl_4$ in rat liver. Methods : Acute liver injury which initiated from free radical induced by $CCl_4$, were applied to rats and data were obtained. Liver injury was estimated by measuring aspartate aminotransferase(AST) and alanine aminotransferase(ALT) activity in serum. Lipid peroxidation was examined by measuring malondialdehyde, a product of lipid peroxidation. GSH activities in liver tissues were also measured. Results : When rats were treated intraperitoneally with $CCl_4$, serum AST and ALT were increased compared with the control, which was significantly inhibited by pretreatment of SPe. SPe also prevented reduction in GSH induced by $CCl_4$. Conclusion : Above results suggest that SPe exerts protective effect against $CCl_4$ by its antioxidant action in liver tissues. Thus, SPe may be used in prevention and treatment of drug-induced liver cell injury. However, the precise mechanisms of SPe protection remain to be determined.

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