The Korea Journal of Herbology (대한본초학회지)
- Volume 21 Issue 4
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- Pages.93-101
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- 2006
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- 1229-1765(pISSN)
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- 2288-7199(eISSN)
Panax notoginseng inhibits LPS-induced pro-inflammatory mediators in microglia
삼칠근(三七根)의 LPS에 의해 활성화된 뇌신경교세포(腦神經膠細胞)로부터의 염증매개물질(炎症媒介物質) 생성억제효과(生成抑制效果)
- Jung, Hyo-Won (Department of Herbology, College of Oriental Medicine, Dongguk University) ;
- Park, Yong-Ki (Department of Herbology, College of Oriental Medicine, Dongguk University)
- Published : 2006.12.30
Abstract
Objectives : Increasing evidence has linked chronic inflammation to a number of neurodegenerative disorders including Alzheimer's disease(AD), Parkinson's disease(PD) and Huntington's disease(HD) in the inflammatory process. Uncontrolled activation of microglia may directly toxic to neurons by releasing various substances such as inflammatory cytokines (
Keywords
- Anti-inflammation;
- BV2 microglial cells;
- IL-6;
- inducible nitric oxide synthase;
- LPS;
- microglia;
- nitric oxide;
- Panax notoginseng;
- $TNF-{\alpha}$