Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Enzymological Evaluation of Bowel Inflammation Inhibitory Activity and Intestinal Microbial Flora Improvement by Enzymatic Hydrolysate of Schizandrae Fructus

오미자 효소가수분해물에 의한 장내 세균총 개선 및 장관 염증 억제 효과의 효소학적 평가

  • Ryu, Il-Hwan (College of Life Science and Natural Resources, Wonkwang University) ;
  • Kwon, Tae-Oh (College of Life Science and Natural Resources, Wonkwang University) ;
  • Lee, Kang-Soo (Facult of Biological Resources Science, Jeonbuk National University) ;
  • Yun, Yong-Gab (Department of Prescription, Wonkwang University School of Oriental Medicine)
  • 류일환 (원광대학교 생명자원과학대학) ;
  • 권태오 (원광대학교 생명자원과학대학) ;
  • 이강수 (전북대학교 농업생명과학대학) ;
  • 윤용갑 (원광대학교 한의과대학)
  • Published : 2007.12.31
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Abstract

Schizandrae Fruits has been used as a traditional Oriental medicine for treatment of many stress-induced diseases. In the present study, we investigated inhibitory activity of enzymatic hydrolysate of Schizandrae fructus (SC-EX) in growth of tested intestinal microorganism and activity of bowel inflammation related enzyme. SC-EX was added to the proteose peptone-yeast extract-fildes (PYF) media to investigation the effect on the growth of type culture of intestinal microorganism. The growth of lactic acid bacteria such as Bifidobacterium species and Lactobacillus species was accelerated by more than 3% concentration of SC-EX. But, growth of harmfulness bacteria such as E.coli, Clostridium sp. Staphylococcus sp. Streptococcus sp. was inhibited by more than 3% concentration of SC-EX. Also, SC-EX was exhibited a concentration-dependent inhibitory activity of the bowel inflammation related enzymes. The SC-EX was showed 76% and 92% inhibitory activity of 5-lipoxygenase and cyclooygenase at 5% additional concentration respectively. Our results indicated that SC-EX may possess improvement effect on the intestinal flora and Anti-inflammatory effect on the bowel.

Keywords

References

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