Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Isolation of Melanogenesis Inhibitors from Cinnamomi Cortex

계피로부터 멜라닌 생성 억제 성분의 분리

  • Published : 2007.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

Cinnamomi Cortex (Lauraceae), the dried bark of Cinnamomum cassia BLUME, has been used as traditional Chinese medicine for its stomachic, astringent, carminative, antispasmodic, antibacterial, antifungal properties. Four compounds were isolated from the MeOH extract of Cinnamomi Cortex, and their structures were identified as trans-cinnamic acid (1), ${\beta}-sitosterol$ (2), bis(2-methylheptyl)phthalate (3), coumarin (4) by comparison of their physical and spectral data with those reported in the literature. These compounds were tested melanogenesis inhibitory effect on B-16 mouse melanoma cell lines. Among them, trans-cinnamic acid (1) showed the most potent inhibitory effect on melanogenesis with $IC_{50}$ value of $13{\mu}g/ml$. Arbutin, positive control, exhibited an $IC_{50}$ value of $29{\mu}g/ml$.

Keywords

References

  1. 生藥學硏究會. (2003) 現代生藥學. 學窓社. 154
  2. Mishima Y., Hatta S., Ohyama Y. (1988) Induction of melanogenesis suppression: cellular pharmacology and mode of differential action. Pigment Cell Res. 1: 367-374 https://doi.org/10.1111/j.1600-0749.1988.tb00136.x
  3. Matubara H. (1998) Inhibitory effect of lichen metabolites and their synthetic analogues on melanin biosynthesis in cultured B-16 mouse melanoma cells. Natural Product Sciences. 4(3): 161-169
  4. Choi, B. W., et al. (1998) Screening of the Tyrosinase Inhibitors from Marine Algae and Medicinal Plants. Kor. J. Pharmacogn. 29(3): 237-242
  5. Matsusukami, M. (1995) Evaluation of antimelanogenic Effects. Frangrance. 19(1): 14
  6. 三島豊. (1983) '色素異常症 : 總論' 現代皮膚科學大系. 第 15券. 山村雄一他論. 東京. 中山書店. 3
  7. Kreiner, P. W., Gold, C. J., Keirns, J. J., Brock, W. A. Bitensky, M. W. (1973) Hormonal control of melanocytes: MSHsensitivity adenyl cyclase in the Cloudman melanoma. Yale J. Biol. Med. 46: 583-591
  8. Giacomini, P. L., Imberti, L., Aguzzi, A., Fisher, P. B., Trinchieri, G., Ferrone, S. (1985) Immunochemical analysis of the modulation of human melanoma-assocated antigens by DNA recombinant immune interferon. J. Immunol., 135: 2887-2894
  9. Gordon, P. R., Naeyaert J. M., Eller M., Park H. Y., Gilchrest B. A. (1991) Pigment content of cultured human melanocyte does not correlate with tyrosinase message level. J. Invest. Dermatol., 125: 297-303
  10. Huong, D. T. L., Jo, Y. S., et al. (2000) Monoamine Oxidase Inhibitors from Cinnamomi Cortex. Natural Product Sciences. 6(1): 16-19
  11. Hanai, K., Kuwae, A., et al. (2001) A comparative vibrational and NMR study of cis-cinnamic acid polymorphs and trans-cinnamic acid. Spectrochimica Acta Part A. 57: 513- 519 https://doi.org/10.1016/S1386-1425(00)00401-7
  12. Greca, M. D., Monaco, P., et al. (1990) Stigmasterol from Typha latifolia. Journal of Natural Products. 53(6): 1430- 1435 https://doi.org/10.1021/np50072a005
  13. Goad L. J., Clague A. D. H. et al. (1976) The 220MHz NMR spectra of phytosterols. Phytochemistry. 15(1): 195-200 https://doi.org/10.1016/S0031-9422(00)89083-4
  14. Rameshthangam, P., Ramasamy, P., et al. (2007) Antiviral activity of bis(2-methylheptyl)phthalate isolated from Pongamia pinnata leaves against White Spot Syndrome Virus of Peaeus monodon Fabricius. Virus Research. 126: 38-44 https://doi.org/10.1016/j.virusres.2007.01.014
  15. Lee, S. E., Kim, M. K., et al. (2000) Inhibitory effects of Cinnamomum cassia Bark-derived materials on Mushroom tyrosinase. Food Science and Biotechnology. 9(5): 330-333
  16. Shi, Y., Chen, Q. X., et al. (2005) Inhibitory effects of cinnamic acid and its derivatives on the diphenolase activity of mushroom (Agaricus bisporus) tyrosinase. Food Chemistry. 92: 707-712 https://doi.org/10.1016/j.foodchem.2004.08.031