Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
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Effect of Pyroligneous Liquor on Lipid Metabolism in Serum of CD Rats

혈청의 지질대사에 미치는 목초액 (Pyroligneous Liquor)의 영향

  • Cho, Weon-Ki (Clinical Dualism Research Institute, Choa Pharmacy Co. Ltd.) ;
  • Choi, Jin-Ho (Laboratory of Biochemistry, Faculty of Food Science and Biotechnology, Pukyong National University)
  • 조원기 (조아제약 양병학종합연구소) ;
  • 최진호 (부경대학교 생화학교실)
  • Published : 2007.01.31
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Abstract

This study was designed to investigate the effects of pyroligneous liquor on lipid metaboilsm in serum of SPF/VAF Cri/Bgi CD rats. Male CD rats were fed basic diet prepared in our Lab., and PL-0 (control), PL-1, PL-25, PL-50, PL-75 groups were prepared with pyroligneous liquor (35% of Choa Co. Ltd.) of 0%, 1%, 25%, 50% and 75% in purified water per day for 8 weeks. Body weights and food intakes almost did not change in these five groups, and triglyceride (TG) levels were significantly decreased (20.5% and 19.5%, respectively) in these PL-25 and PL-50 groups compared with control group. Total and LDL-cholesterol levels were markedly decreased (20.7%, 16.3% and 20.3%, 116.9%, respectively) in these PL-25 and PL-50% groups, but HDL-cholesterol levels were significantly increased about 36.4% and 25.5% in serum of PL-25 and PL-50 groups compared with control group. Atherogenic indices were also remarkedly decreased (63.0%, and 50%, respectively) in these PL-25 and PL-50 groups compared with control group. These results suggest that long term administration orally of pyroligneous liquor in 25 to 50% may inhibit chronic degenerative disease through improving of lipid metabolism of lower TG & LDL-cholesterol and higher HDL-cholesterol, and lower AJ.

목초액 투여가 생체 지질대사에 미치는 영향을 평가하기 위하여 조아제약에서 개발하여 특허출원한 목초액에서 조제한 시판 목초액 (원액 35% 상당)을 사용하여 0%, 1.0%, 25.0%, 50.0%, 75.0%가 되도록 조제 (control, PL-1, PL-25, PL-50, PL-75 groups)하여 실험용 조제사료로써 8주 동안 자유 음용시킨 다음, 목초액의 지질대사에 미치는 영향을 평가하였다. 목초액 투여에 의한 체중변화 및 사료 섭취률에는 유의적인 영향을 주지 못했다. 그렇지만, 혈청 중의 중성지질의 영향은 목초액 PL-25 및 PL-50 투여군은 대조군 대비 20.5% 및 19.5%의 매우 유의적인 억제효과가 인정되었고, 목초액 PL-75 투여군도 대조군 대비 12%의 유의적인 감소효과가 인정되었다. 목초액 PL-25 및 PL-50 투여군의 총콜레스테롤은 대조군 대비 79.3% 및 83.7%로서 20.7% 및 16.3%의 매우 유의적인 총콜레스테롤 억제효과가 인정되었다. 또한 목초액 PL-25 및 PL-50 투여군은 20.3% 및 16.9%의 유의적 LDL-콜레스테롤의 억제효과가 인정되었을 뿐만 아니라 36.4% 및 25.5%의 HDL-콜레스테롤의 증가효과가 인정되었다. 목초액 PL-25 및 PL-50 투여군은 대조군 대비 각각 37.0% 및 50.0%로 매우 유의적인 동맥경화지수 (AI)의 억제효과가 나타났다. 따라서 목초액의 장기간 투여는 중선지질, 총콜레스테롤 및 LDL-콜레스테롤을 효과적으로 억제할 뿐만 HDL-콜레스테롤을 효과적으로 증가시켜 동맥경화지수(AI)도 효과적으로 억제할 수 있기 때문에 목초액의 장기투여는 성인병의 예방에 효과적일 것으로 기대된다.

Keywords

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