YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Anti-nociceptive, Anti-inflammatory, Mental Effects of Essential Oil from Thymus magnus

섬백리향 정유의 진통, 항염증, 정신적인 작용

  • Kim, Sun-Min (College of Pharmacy, Catholic University of Daegu) ;
  • Suk, Kui-Duk (College of Pharmacy, Catholic University of Daegu)
  • 김성민 (대구가톨릭대학교 약학대학) ;
  • 석귀덕 (대구가톨릭대학교 약학대학)
  • Published : 2007.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

Thymus magnus is an endemic (Ulleung Island) species in Korea. This plant is used as diaphoretics and carminatives in traditional medicine. In the literature, few scientific assays were realized on this species, such as antibiotic (Streptococcus pneumoniae, Staphylococcus aureus, Salmonella enteritidis, and S. typhimurium) and antifungal activities. In order to clarify whether essential oil of T. magnus have pharmacological effects, anti-inflammatory, sedative, anti-depressant, analgesic, and sleep-prolonged effects were investigated using animal models. From this study, the following conclusions were attained; 1) Essential oil of T. magnus did not show any acute toxicity on mice when orally administered at the dose of 2-3 g/kg body weight. 2) Essential oil of T. magnus possessed strong anti-inflammatory activity, similar to that of a positive control prednisolone. 3) Essential oil of T. magnus had excellent analgesic activity, comparable to that of aspirin. 4) The essential oil of T. magnus possessed strong sleep-prolonged effect on pentobarbital induced-sleep test in mice model. 5) In the hot plate test, the essential oil of T. magnus had moderate effect. 6) And the essential oil of T. magnus had no significant effects in forced-swimming test and open-field test.

Keywords

References

  1. Battaglia, S. : The Complete Guide to Aromatherapy, Australian Academic Press, Brisbane, Australian (2003)
  2. Cho, S. J. : Psychoaromatherapy. J. Integ. Altern. Med. 1, 23 (2005)
  3. Buckle, J. : Aromatherapy in parianesthesia nursing. J. PeriAnesthesia Nurs. 14(6), 336 (1999)
  4. Park, K. W. : Healthy function and research situation of herbs in Korea. Trend Agr. Life Sci. 2(1), 27 (2002)
  5. Son, B. K. : A study on the usage type and satisfaction grade of massage therapy as complementary & alternative medicine. J. Integ Altern. Med. 1, 51 (2005)
  6. Han, D. S. and Kim, K. W. : Studies on the essential oil components of Thymus magnus Nakai. Kor. J. Pharmacog. 11(1), 1 (1980)
  7. Kim, Y. H., Lee, J. C. and Cho, Y. H.: Essential oils of Thymus quinquecostatus Celakov. and Thymus magnus Nakai. Korea J. Medicinal Crop Sci. 2(3), 234 (1994)
  8. Thomas, H. : Isolation of volatile components from a model system. J. Agric. Food Chem. 25(3), 445 (1977)
  9. Shin, S. W and Kim, J. H.: Antifungal activities of essential oils from Thymus quinquecostatus and T magnus. Planta Med. 70(1), 1090 (2004) https://doi.org/10.1055/s-2004-832654
  10. Shin, S. W. and Kim, J. H. : In vitro inhibitory activities of essential oils from two Korean Thymus species against antibiotic-resistant pathogens. Arch. Pharm. Res. 28(8), 897 (2005) https://doi.org/10.1007/BF02973874
  11. Oussalah, M.: Inhibitory effects of selected plant essential oils on the growth of four pathogenic bacteria: E. coli 0157:H7, Salmonella Typhimurium, Staphylococcus aureus and Listeria monocytogenes. Food Control 18, 414 (2007) https://doi.org/10.1016/j.foodcont.2005.11.009
  12. Marino, M. : Antimicrobial activity of the essential oils of Thymus vulgaris L. measured using a bioimpedometric method. J. Food Prot. 62(9), 1017 (1999) https://doi.org/10.4315/0362-028X-62.9.999
  13. Soliman, K. M. : Effect of oil extracted from some medicinal plants on different mycotoxigenic fungi. Food Chem. Toxicol. 40(11), 1669 (2002)
  14. Van Den Broucke, C. O. and Lemli, J. A.: Spasmolytic activity of the flavonoids from Thymus vulgaris. Pharmaceu. Weekblad Sci. 5, 9 (1983)
  15. Miura, K. : Antioxidant activity of chemical components from sage (Salvia officinalis L.) and thyme (Thymus vulgaris L.) measured by the oil stability index method. 1. J. Agr. Food Chem. 50(7), 1845 (2002)
  16. Chevallier, A. : Herbal Remedies, A Dorling Kindersley Book, p. 86 (2001)
  17. 식품의약품안전청 기능성 화장품등의 심사에 관한 규정. 식품의약품안전청 고시 제 2006-43호 (2006.9.19)
  18. Kim, D. W. and Chi, Y. S. : Effects of sophoraflavanone G, a prenylated flavonoid from Sophora flavescens, on cyclooxygenase-2 and in vivo inflammatory response. Arch. Pharm. Res. 25(3), 329 (2002)
  19. Lee, S. J. : Antiinflammatory activity of Lonicera japonica. Phytoth. Res. 12, 445 (1998)
  20. Inoue, H.: sulfidopeptide-leukotrienes are major mediators of arachidonic acid-induced mouse ear edema. Prostaglandins 36(5), 731 (1988)
  21. Park, J. E. and Choi, H. J. : Analgesic and antiinflammatory activities of some oriental herbal medicines. Kor. J. Pharmacogn. 32(4), 257 (2001)
  22. Loro, J. E : Preliminary studies of analgesic and antiinflammatory properties of Opuntia dillenii aqueous extract. J. Ethnopharmacol. 67, 213 (1999)
  23. Habazi, K. E. : Study on the antinociceptive effects of Thymus broussonetii Boiss extracts in mice and rats. J. Ethnopharmacol. 107, 406 (2006) https://doi.org/10.1016/j.jep.2006.03.029
  24. Kogi, W. : Sedative, analgesic, and sleep-prolonged effects to the mouse of commercial essential oils. Aroma Res. 4(3), 249 (2003)
  25. Eaton, M. : Common animal models for spasticity and pain. J. Rehabil. Res. Dev. 40(4), 41 (2003) https://doi.org/10.1682/JRRD.2003.08.0041
  26. Kobayashi, Y. : Antidepressant effect of the Atracylodes japonica essential oil in mice. Aroma Res. 6(4), 356 (2005)
  27. John, E : The Neuropeptide Y (NPY) Yl receptor subtype mediates NPY-induced antidepressant-like activity in the mouse forced swimming test. Neuropsychopharmacol. 25(5), 615 (2002)
  28. Lori, A. : Sex differences in forced-swim and open-field test behaviours after chronic administration of melatonin. Eur. J. Pharmacol. 402, 87 (2000)
  29. Lynn, G. : Interaction between the forced swimming test and fluoxetine treatment on extracellular 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in the rat. J. Pharmacol. Exp. Ther. 282(2), 967 (1997)
  30. Matthew, W.: Hale, exposure to high- and low-light conditions in an open-field test of anxiety increases c-fos expression in specific subdivisions of the rat basolateral amygdaloid complex. Brain Res. Bull. 71, 174 (2006) https://doi.org/10.1016/j.brainresbull.2006.09.001
  31. Erden, B. E : The effect of 7-nitro imidazole on pentobarbital-induced sleep in mice. Pharmacol. Res. 36(4), 265 (1997)
  32. 한국약학대학협의회 약물학분과회, 약물학.독성학 실험, 신일상사,pp. 154-157 (2004)
  33. Atsumi, T. : Enhancement effect of aromatherapy on free radical scavenging activity and stress. Aroma Res. 7(1), 44 (2006)
  34. Inoue, H.: Sulfidopeptide-leukotrienes are major mediators of arachidonic acid-induced mouse ear edema. Prostaglandins 36(5), 731 (1988)