Food Science and Biotechnology

Korean Society of Food Science and Technology (한국식품과학회)
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Antigenotoxic Effect of Paecilomyces tenuipes Cultivated on Soybeans in a Rat Model of 1,2-Dimethylhydrazine-induced Colon Carcinogenesis

  • Park, Eun-Ju (Department of Food and Nutrition, Kyungnam University) ;
  • Jeon, Gyeong-Im (Department of Food and Nutrition, Kyungnam University) ;
  • Park, Nam-Sook (Department of Life Science and Environmental Biochemistry, College of Natural Resources and Life Science, Pusan National University/Joint Research Center of PNU-Fraunhofer IGB) ;
  • Jin, Byung-Rae (College of Natural Resources and Life Science, Dong-A University) ;
  • Lee, Sang-Mong (Department of Life Science and Environmental Biochemistry, College of Natural Resources and Life Science, Pusan National University/Joint Research Center of PNU-Fraunhofer IGB)
  • Published : 2007.12.31
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Abstract

We evaluated the effect of soybean dongchunghacho [SD, cultivated dongchunghacho fungus (Paecilomyces tenuipes) on soybeans] on dimethylhydrazine (DMH)-induced DNA damage and oxidative stress in male F344 rats. The animals were divided into 3 groups and fed a casein-based high-fat, low fiber diet without (DMH group) or with 13%(w/w) of soybean (DMH+S group), or SD (DMH+SD group). One week after beginning the diets, rats were treated weekly with DMH (30 mg/kg, s.c.) for 6 weeks; dietary treatments were continued for the entire experiment and endpoints measured at 9 weeks after the first DMH injection. SD supplementation reduced DMH-induced DNA damage in colon cells and reduced plasma lipid peroxidation. Thus, SD may have therapeutic potential for early-stage colon carcinogenesis.

Keywords

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