Korean Journal of Food Science and Technology (한국식품과학회지)

Korean Society of Food Science and Technology (한국식품과학회)
권호 표지

Tissue Concentration of Quercetin, Isoquercitrin and Hyperoside, and Lipid Profile Changes Following 8-Week Feeding of Angelica keiskei Powder in Rats

백서에서 신선초 8주 투여에 의한 quercetin, isoquercitrin 및 hyperoside의 체내농도 및 혈중 지질함량 변화

  • Choe, Kyu-Hong (Department of Food Science & Engineering, Kunsan National University) ;
  • Choe, Sun-Nam (Department of Food Science & Engineering, Kunsan National University) ;
  • Choo, Jong-Jae (Department of Food Science & Nutrition, Kunsan National University) ;
  • Lee, Jeong-Yeol (Faculty of Marine Life Science, Kunsan National University) ;
  • Kim, Jong-Yeon (Faculty of Marine Life Science, Kunsan National University) ;
  • Kim, Ju-Wan (Department of Aquatic Life Medicine, Kunsan National University) ;
  • Choi, Ji-Sung (Department of Aquatic Life Medicine, Kunsan National University) ;
  • Park, Ki-Seok (Department of Aquatic Life Medicine, Kunsan National University) ;
  • Park, Kwan-Ha (Department of Aquatic Life Medicine, Kunsan National University)
  • 최규홍 (군산대학교 해양과학대학 식품공학과) ;
  • 최선남 (군산대학교 해양과학대학 식품공학과) ;
  • 주종재 (군산대학교 자연과학대학 식품영양학과) ;
  • 이정열 (군산대학교 해양과학대학 해양생명과학부) ;
  • 김종연 (군산대학교 해양과학대학 해양생명과학부) ;
  • 김주완 (군산대학교 해양과학대학 수산생명의학과) ;
  • 최지성 (군산대학교 해양과학대학 수산생명의학과) ;
  • 박기석 (군산대학교 해양과학대학 수산생명의학과) ;
  • 박관하 (군산대학교 해양과학대학 수산생명의학과)
  • Published : 2007.12.01
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Abstract

In this study, we examined the effects of Angelica keiskei (AK) in rats, in order to evaluate tissue quercetin concentrations and serum lipid profile changes. Dried AK powder was added to a regular chow at a 5% level, and fed for 8 weeks to male rats. AK significantly lowered serum total cholesterol, low-density lipoprotein cholesterol, and very low-density lipoprotein cholesterol levels, while it increased high-density lipoprotein cholesterol levels. However, AK did not influence serum triglyceride levels. Two antioxidant flavonoids present in AK, quercetin and its glycoside isoquercitrin, were detected in the serum and liver of the rat. However, another quercetin glycoside, hyperoside, was not detected in either the serum or liver despite its presence in the diet. These results indicate that AK seems to alter serum lipid concentrations, possibly through the body's absorption of certain quercetin glycosides.

신선초의 건조분말을 사료에 5%수준으로 혼합하여 백서에 8주간 투여하였을 때, 총 cholesterol, LDL-cholesterol, VLDL-cholesterol의 농도를 낮추며, HDL-cholesterol의 농도는 높이는 효과가 있음이 관찰되었다. 신선초에 존재한다고 알려진 항산화성 flavonoid들 중 quercetin과 그 배당체의 하나인 isoquercitrin이 백서의 체내에서 측정된 반면, 다른 quercetin 배당체인 hyperoside는 측정되지 않았다. 이 결과는 장기간 신선초투여에 의해 신선초에 함유된 quercetin 또는 그 배당체가 실제로 체내로 흡수되어 약리작용을 발휘할 수 있을 가능성을 제시해 준다.

Keywords

References

  1. Shim JS, Kim SD, Kim TS, Kim KN. Biological activities of flavonoid glycosides isolated from Angelica keiskei. Korean J. Food Sci. Technol. 37: 78-83 (2005)
  2. Park JC, Yu YB, Lee LH. Chemical components from the aerial parts of Angelica keiskei. Korean J. Pharmacogn. 27: 80-82 (1996)
  3. Park JC, Cho YS, Park SK, Park JR, Jeon SS, OK KD, Choi JW. Isolation of flavone-7-O-glucosides from the aerial parts of Angelica keiskei and anti-hyperlipidemic effect. Korean J. Pharmacogn. 26: 337-373 (1995)
  4. Chun SS, Park JC, Kim SH, Lee DY, Choi HM, Hwang EY. Changes in biologically active component of Angelica keiskei by cooking methods. J. Korean Soc. Food Sci. Nutr. 27: 121-125 (1998)
  5. Hertog MGL, Hollman PCH, Van der Putte B. Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in the Netherlands. J. Agr. Food Chem. 40: 2397-2383 (1992)
  6. Hertog MGL, Hollman PCH, Van der Putte B. Content of potentially anticarcinogenic flavonoids of tea infusions, wines, and fruit juices. J. Agr. Food Chem. 41: 1242-1246 (1993) https://doi.org/10.1021/jf00032a015
  7. Hollman PCH, Kstan MB. Absorption, metabolism, and health effects of dietary flavonoids in man. Biomed. Pharmacother. 51: 305-310 (1997) https://doi.org/10.1016/S0753-3322(97)88045-6
  8. Hertog MGL, Kromhaut D, Aravanis C, Blackburn H, Buzina R, Fidanza F, Giampaoli S, Jansen A, Menotti A. Flavonoid intake and long-term risk of coronary heart disease and cancer in the seven countries study. Arch. Intern. Med. 155: 381-386 (1995) https://doi.org/10.1001/archinte.155.4.381
  9. Kim JS, Kim HY, Park YK, Kim TS, Kang MH. The effects of green vegetable juice (Angelica keiskei) supplementation on plasma lipids and antioxidant status in smokers. Korean J. Nutr. 36: 933-941 (2003)
  10. Park JR, Park SK, Cho YS, Chun SS, Choi SH, Park JC. Effects of Angelica keiskei on lipid metabolism in rats. J. Korean Soc. Food Sci. Nutr. 26: 308-313 (1997)
  11. Piskula MK, Terao J. Quercetin's solubility affects its accumulation in rat plasma after oral administration. J. Agr. Food. Chem. 46: 4313-4317 (1998) https://doi.org/10.1021/jf980117v
  12. Chang Q, Zhu M, Zuo Z, Chow M. High-performance liquid chromatographic method for simultaneous determination of hawthorn active compounds in rat plasma. J. Chromatogr. B 760: 227-235 (2001) https://doi.org/10.1016/S0378-4347(01)00273-0
  13. Merken HM, Beecher GR. Liquid chromatographic method for the separation and quantification of prominent aglycones. J. Chromatogr. A 897: 177-184 (2000) https://doi.org/10.1016/S0021-9673(00)00826-8
  14. Manach C, Morand C, Demigné C, Régérat F, Dimigné C, Rémésy C. Comparison of the bioavailability of quercetin and catechin in rats. Free Radical. Bio. Med. 27: 1259-1266 (1999) https://doi.org/10.1016/S0891-5849(99)00159-8
  15. Chang Q, Zuo Z, Chow MS, Ho WK. Difference in absorption of the two structurally similar flavonoid glycosides, hyperoside and isoquercitrin, in rats. Eur. J. Pharm. Biopharm. 509: 549-555 (2005)
  16. Choi BG, Vilahur G, Viles-Gonzalez JF, Badimon JJ. The role of high-density lipoprotein cholesterol in atherothrombosis. Mt. Sinai J. Med. 73: 690-701 (2006)