The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Enhancing effect of Multiherb extracts HT008-1 on Memory and Cognitive Function

한약복합물 HT008-1의 인지기능 및 기억력 향상효과

  • Seo, Joo-Hee (Dept. of Oriental Neuropsychiatry, National Medical Center) ;
  • Woo, So-Young (Dept. of East-West Medical Science, Graduate School East-West Medical Science, Kyung Hee University) ;
  • Kim, Yun-Tai (Dept. of Herbal Pharmacology, College of Oriental Medicine, Kyung Hee University) ;
  • Kim, Mi-Yeon (Dept. of Herbal Pharmacology, College of Oriental Medicine, Kyung Hee University) ;
  • Jin, Zhen-Hua (Dept. of Herbal Pharmacology, College of Oriental Medicine, Kyung Hee University) ;
  • Park, Young-Mi (Dept. of Herbal Pharmacology, College of Oriental Medicine, Kyung Hee University) ;
  • Bu, Young-Min (Dept. of Herbal Pharmacology, College of Oriental Medicine, Kyung Hee University) ;
  • Kim, Ho-Cheol (Dept. of Herbal Pharmacology, College of Oriental Medicine, Kyung Hee University)
  • 서주희 (국립의료원 한방신경정신과) ;
  • 우소영 (경희대학교 동서의학대학원 동서의학과) ;
  • 김윤태 (경희대학교 한의과대학 본초학교실) ;
  • 김미연 (경희대학교 한의과대학 본초학교실) ;
  • 김진화 (경희대학교 한의과대학 본초학교실) ;
  • 박영미 (경희대학교 한의과대학 본초학교실) ;
  • 부영민 (경희대학교 한의과대학 본초학교실) ;
  • 김호철 (경희대학교 한의과대학 본초학교실)
  • Published : 2007.12.31
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Abstract

Objectives : Investigation of the memory and cognitive enhancing effect of HT008-1 in scopolamine induced amnesia mice. Methods : At 60 min before acquisition trials, HT008-1 (30, 100, 300 mg/kg p.o.) was administered, and 30 min later, mice were injected with scopolamin (1.0 mg/kg, i.p.). In the passive avoidance test, acquisition trials were carried out 30 min after a single scopolamine treatment. Retention trials were carried out 24h after acquisition trials. Y-maze test was carried out 30 min after a single scopolamine treatment. Spontaneous alternation behavior during an 8-min session was recorded. Inhibitory effects of HT008-1 (0.01, 0.1, 1.0 mg/ml) on AChE activity was measured. Result : HT008-1 ameliorated scopolamine-induced learning impairments and spatial cognitive function in passive avoidance and Y-maze test, respectively. Moreover HT008-1 showed a significant inhibitory effect on AChE activity. Discussion: This study presented that eMultiherb mixture HT008-1 enhanced learning memory and spatial cognitive function in scopolamine-induced amnesia mice. These results suggest that the effect of HT008-1 may be dependent on the inhibition of AChE activity.

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