The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Inhibitory Effects of Nelumbo nucifera on Tyrosinase Activity and Melanogenesis in Clone M-3 Melanocyte Cells

연잎, 연꽃 및 연꽃 수술 추출물의 Tyrosinase 활성억제 및 Melanin 생성억제에 의한 미백 효과

  • Park, Seong-Kyu (Dept. of Prescriptionology, College of Oriental Medicine, Kyung Hee University) ;
  • Chang, Mun-Seog (Dept. of Prescriptionology, College of Oriental Medicine, Kyung Hee University) ;
  • Kim, Hyang-Mi (Dept. of Prescriptionology, College of Oriental Medicine, Kyung Hee University) ;
  • Yang, Woong-Mo (Dept. of Prescriptionology, College of Oriental Medicine, Kyung Hee University) ;
  • Kim, Do-Rim (Dept. of Prescriptionology, College of Oriental Medicine, Kyung Hee University) ;
  • Park, Eun-Hwa (Dept. of Prescriptionology, College of Oriental Medicine, Kyung Hee University) ;
  • Ko, Eun-Bit (Dept. of Prescriptionology, College of Oriental Medicine, Kyung Hee University) ;
  • Choi, Moon-Jung (Dept. of Prescriptionology, College of Oriental Medicine, Kyung Hee University) ;
  • Kim, Hyu-Young (Dept. of Prescriptionology, College of Oriental Medicine, Kyung Hee University) ;
  • Oh, Ji-Hoon (Dept. of Prescriptionology, College of Oriental Medicine, Kyung Hee University) ;
  • Shim, Kyung-Jun (Dept. of Prescriptionology, College of Oriental Medicine, Kyung Hee University) ;
  • Yoon, Ji-Won (Dept. of Prescriptionology, College of Oriental Medicine, Kyung Hee University)
  • 박성규 (경희대학교 한의과대학 처방제형학교실) ;
  • 장문석 (경희대학교 한의과대학 처방제형학교실) ;
  • 김향미 (경희대학교 한의과대학 처방제형학교실) ;
  • 양웅모 (경희대학교 한의과대학 처방제형학교실) ;
  • 김도림 (경희대학교 한의과대학 처방제형학교실) ;
  • 박은화 (경희대학교 한의과대학 처방제형학교실) ;
  • 고은빛 (경희대학교 한의과대학 처방제형학교실) ;
  • 최문정 (경희대학교 한의과대학 처방제형학교실) ;
  • 김휴영 (경희대학교 한의과대학 처방제형학교실) ;
  • 오지훈 (경희대학교 한의과대학 처방제형학교실) ;
  • 심경준 (경희대학교 한의과대학 처방제형학교실) ;
  • 윤지원 (경희대학교 한의과대학 처방제형학교실)
  • Published : 2007.12.31
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Abstract

Objectives : We examined three parts of Nelumbo nucifera that might be useful for skin-whitening effect. Each parts of leaves, flowers and stamen were extracted with water or 70% ethanol. Methods : This study investigated inhibitory effects of each extracts on tyrosinase activity. Extracts were tested for cytotoxicity on clone M-3 melanocyte cells, melanin inhibitory activities were further assessed. Results : The water extract of Nelumbo nucifera stamen. ethanol and water extracts of flowers exhibited inhibitory effects on tyrosinase (IC50 values 726.16, 1063, and 1732.36 ug/mL, respectively). The water extract of Nelumbo nucifera stamen, ethanol extract of flowers, both ethanol and water extracts of leaves showed relatively lower cytotoxicity, with cell viability above 80% with a concentration of 20 ${\mu}g/mL$. In addition, The water extract of Nelumbo nucifera stamen inhibited the melanin production in clone M-3 melanocyte cells. Conclusions : Among each parts of Nelumbo nucifera. the water extract of stamen was the strongest candidates for skin-whitening cosmetic application.

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