Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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Analysis of Studies on Palmul-tang for Establishment of Evidence Based Medicine

EBM 기반 구축을 위한 팔물탕 문헌 연구 분석

  • Ma, Choong-Je (Dept. of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine) ;
  • Lee, Nam-Hun (Dept. of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine) ;
  • Ma, Jin-Yeul (Dept. of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine) ;
  • Ha, Hye-Kyung (Dept. of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine) ;
  • Yu, Young-Beob (Dept. of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine) ;
  • Shin, Hyun-Kyoo (Dept. of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine)
  • 마충제 (한국한의학연구원 한약제제연구부) ;
  • 이남헌 (한국한의학연구원 한약제제연구부) ;
  • 마진열 (한국한의학연구원 한약제제연구부) ;
  • 하혜경 (한국한의학연구원 한약제제연구부) ;
  • 유영법 (한국한의학연구원 한약제제연구부) ;
  • 신현규 (한국한의학연구원 한약제제연구부)
  • Published : 2007.12.30
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Abstract

Objective : The purpose of this report was to provide the information activity and safety of Palmul-tang by analyzing domestic/international papers and theses about Palmul-tang, Methods: Domestic/international papers and theses related to Palmul-tang were reviewed and analyzed, These papers were then classified by year, experimental method and subject, Results: The following results were obtained in this study. 1. The study of Palmul-tang started from 1985 and was continuously increased. The study was mainly forcused on experimental model rather than clinical study. 2. As these studies were classified by subject, papers related to immune intensification were most abundant by 20 papers, Besides there were several papers related to cardiovascular activity, reproductive activity, anti-apoptotic activity and cerebral hemodynamics. 3. Among the papers related to immune intensification. the studies on recovery of fatigue were mostabundant by 10 papers and the studies of on immune cell and cytokine express were six. In addition to. several studies were associated with anti-cancer activity and anti-allergic activity. Recovery of fatigue was determined by measurement of fatigue markers in a living body such as lactate. CPK, pyruvate and triglyceride and assessment of exercise capability of animals such as swimming test. slopped plate test. Rota-rod test, and activity cage test after Palmul-tang treatment. 4. According to experimental data. it is supported that Palmul-tang has been used as Qi and Blood intensifier with immune intensification and recovery of fatigue. 5. The paper related to safety of Palmul-tang was only one paper which is studied on acute toxicity of Palmul-tang with experiment with ICR mouse. There was no study on evaluating safety by observing liver and kidney functions after Palmul-tang treatment Conclusion: Palmul-tang is being used in various ways associating with immune intensification. cardiovascular activity and reproductive activity. However. studies on efficacy and mechanism of Palmul-tang should be conducted at the molecular biology level and studies on safety of Palmul-tang need to be completed at the clinical level.

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