Endocrinology and Metabolism

The Korean Endocrine Society (대한내분비학회)
권호 표지

Leptin Resistance

렙틴 저항성

Kim, Yong-Woon
김용운

  • Published : 20071000
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Abstract

Keywords

References

  1. Kennedy GC: The role of depot fat in the hypothalamic control of food intake in the rats. Proc R Soc Lond B Biol Sci 140:578-596, 1953
  2. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM: Positional cloning of the mouse obese gene and its human homologue. Nature 372 (6505):425-432, 1994 https://doi.org/10.1038/372425a0
  3. Banks W A, DiPalma CR, Farrell CL: Impaired transport of leptin across the blood-brain barrier in obesity. Peptides 20(11):1341-1345, 1999 https://doi.org/10.1016/S0196-9781(99)00139-4
  4. El-Haschimi K, Pierroz DD, Hileman SM, Bjorbaek C, Flier JS: Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity. J Clin Invest 105(12):1827-1832, 2000 https://doi.org/10.1172/JCI9842
  5. Banks WA, Coon AB, Robinson SM, Moinuddin A, Shultz JM, Nakaoke R, Morley JE: Triglycerides induce leptin resistance at the blood-brain barrier. Diabetes 53: 1253-1260. 2004 https://doi.org/10.2337/diabetes.53.5.1253
  6. Oh-I S, Shimizu II, Sato T, Uehara Y, Okada S, Mori M: Molecular mechanisms associated with leptin resistance: n-3 polyunsaturated fatty acids induce alterations in the tight junction of the brain. Cell Metab 1:331-341, 2005 https://doi.org/10.1016/j.cmet.2005.04.004
  7. Dietrich MO, Spuch C, Antequera D, Rodal I, de Yebenes JG, Molina JA, Bermejo F, Carro E: Megalin mediates the transport of leptin across the blood-CSF barrier. Neurobiol Aging, in press, 2007
  8. Kim YW, Kim JY, Park YH, Park SY, Won KC, Choi KH, Huh JY, Moon KH: Metforrnin restores leptin sensitivity in high-fat-fed obese rats with leptin resistance. Diabetes 55(3):716-724, 2006 https://doi.org/10.2337/diabetes.55.03.06.db05-0917
  9. Hileman SM, Pierroz DD, Masuzaki H, Bjorbaek C, El-Haschimi K, Banks WA, Flier JS: Characterization of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity. Endocrinology 143:775-783, 2002 https://doi.org/10.1210/en.143.3.775
  10. Sahu A, Nguyen L, O'Doherty RM: Nutritional regulation of hypothalamic leptin receptor gene expression is defective in diet-induced obesity. J Neuroendocrinol 14:887-893, 2002 https://doi.org/10.1046/j.1365-2826.2002.00856.x
  11. Baskin DG, Seeley RJ, Kuijper JL, Lok S, Weigle DS, Erickson JC, Pahniter RD, Schwartz MW: Increased expression of mRNA for the long form of the leptin receptor in the hypothalamus is associated with leptin hypersensitivity and fasting. Diabetes 47:538-543, 1998 https://doi.org/10.2337/diabetes.47.4.538
  12. Peiser C, Mcgregor GP, Lang RE: Leptin receptor expression and suppressor of cytokine signaling transcript levels in high-fat -fed rats. Life Sci 67 :29712981, 2000
  13. Carvalheira JB, Siloto RM, Ignacchitti I, Brenelli SL, Carvalho CR, Leite A, Velloso LA, Gontijo JA, Saad MJ: Insulin modulates leptin-induced STAT3 activation in rat hypothalamus. FEBS Lett 500: 119124, 2001
  14. Daniel JA, Thomas MG, Hale CS, Simmons JM, Keisler DH: Effect of cerebroventricular infusion of insulin and (or) glucose on hypothalamic expression of leptin receptor and pituitary secretion of LH in diet-restricted ewes. Domest Anim Endocrinol 18:177-185, 2000 https://doi.org/10.1016/S0739-7240(99)00077-6
  15. Tortoriello DV, McMinn JE, Chua SC: Increased expression of hypothalamic leptin receptor and adiponectin accompany resistance to dietary-induced obesity and infertility in female C57BL/6J mice. Int J Obes (Lond) 31:395-402, 2007 https://doi.org/10.1038/sj.ijo.0803392
  16. Keen-Rhinehart E, Kalra SP, Kalra PS: AAV-mediated leptin receptor installation improves energy balance and the reproductive status of obese female Koletsky rats. Peptides 26:2567-2578, 2005 https://doi.org/10.1016/j.peptides.2005.05.027
  17. Martin TL, Alquier T, Asakura K, Furukawa N, Preitner F, Kahn BB: Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscle. J Biol Chem 281(28):18933-18941, 2006 https://doi.org/10.1074/jbc.M512831200
  18. Howard JK, Cave BJ, Oksanen LJ, Tzameli I, Bjorbaek C, Flier JS: Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of SOCS3. Nat Med 10:734-738, 2004 https://doi.org/10.1038/nm1072
  19. Bjornhohn M, Munzberg H, Leshan RL, Villanueva EC, Bates SH, Louis GW, Jones JC, Ishida-Takahashi R, Bjorbaek C, Myers Jr. MG: Mice lacking inhibitory leptin receptor signals are lean with normal endocrine function. J Clin Invest 117(5):1354-1360, 2007 https://doi.org/10.1172/JCI30688
  20. Ren D, Zhou Y, Morris D, Li M, Li Z, Rui L: Neuronal SH2Bl is essential for controlling energy and glucose homeostasis. J Clin Invest 117(2):397406, 2007 https://doi.org/10.1172/JCI29417
  21. Wilsey J, Matheny MK, Scarpace PJ: Oral vanadium enhances the catabolic effects of central leptin in young adult rats. Endocrinology 147(1):493-501, 2006 https://doi.org/10.1210/en.2004-1358
  22. Kim YW, Choi DW, Park YH, Huh JY, Won KC, Choi KH, Park SY, Kim JY, Lee SK: Leptin-like effects of MTII are augmented in MSG-obese rats. Regul Pept 127(1-3):63-70, 2005 https://doi.org/10.1016/j.regpep.2004.12.010
  23. Li G, Zhang Y, Wilsey JT, Scarpace PJ: Hypothalamic pro-opiomelanocortin gene delivery ameliorates obesity and glucose intolerance in aged rats. Diabetologia 48(11):2376-2385, 2005 https://doi.org/10.1007/s00125-005-1943-8
  24. Kim MS, Park JY, Namkoong C, lang PG, Ryu JW, Song HS, Yun JY, Namgoong IS, Ha J, Park IS, Lee IK, Viollet B, Youn JH, Lee HK, Lee KU: Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase. Nat Med 10(7):727-733, 2004 https://doi.org/10.1038/nm1061
  25. Steinberg GR, Watt MJ, Fam BC, Proietto J, Andrikopoulos S, Allen AM, Febbraio MA, Kemp BE: Ciliary neurotrophic factor suppresses hypothalamic AMP-kinase signaling in leptin-resistant obese mice. Endocrinology 147(8):3906-3914, 2006 https://doi.org/10.1210/en.2005-1587
  26. Benomar Y, Wetzler S, Larue-Achagiotis C, Djiane J, Tome D, Taouis M: In vivo leptin infusion impairs insulin and leptin signalling in liver and hypothalamus. Mol Cell Endocrinol 242(1-2):59-66, 2005 https://doi.org/10.1016/j.mce.2005.06.005
  27. Scarpace PJ, Matheny M, Zhang Y, Shek EW, Prima V, Zolotukhin S, Turner N: Leptin-induced leptin resistance reveals separate roles for the anorexic and thermogenic responses in weight maintenance. Endocrinology 143(8):3026-3035, 2002 https://doi.org/10.1210/en.143.8.3026
  28. Scarpace PI, Matheny M, Turner N, Cheng KY, Zhang Y: Leptin resistance exacerbates diet-induced obesity and is associated with diminished maximal leptin signalling capacity in rats. Diabetologia 48(6): 1075-1083, 2005 https://doi.org/10.1007/s00125-005-1763-x
  29. Wilsey J, Scarpace PJ: Caloric restriction reverses the deficits in leptin receptor protein and leptin signaling capacity associated with diet-induced obesity: role of leptin in the regulation of hypothalamic long-form leptin receptor expression. J Endocrinol 181(2):297306, 2004
  30. Banks WA, Farrell CL: Impaired transport of leptin across the blood-brain barrier in obesity is acquired and reversible. Am J Physiol Endocrinol Metab 285:E10-E15, 2003 https://doi.org/10.1152/ajpendo.00468.2002
  31. Levin BE, Dunn-Meynell AA, Banks WA: Obesityprone rats have normal blood-brain barrier transport but defective central leptin signaling before obesity onset. Am J Physiol Regul Integr Comp Physiol 286: R143-R150, 2004 https://doi.org/10.1152/ajpregu.00393.2003
  32. Satoh N, Ogawa Y, Katsuura G, Numata Y, Tsuji T, Hayase M, Ebihara K, Masuzaki H, Hosoda K, Yoshimasa Y, Nakao K: Sympathetic activation of leptin via the ventromedial hypothalamus: leptin-induced increase in catecholamine secretion. Diabetes 48:1787-1793, 1999 https://doi.org/10.2337/diabetes.48.9.1787
  33. Hubschle T, Thorn E, Watson A, Roth J, Klaus S, Meyerhof W: Leptin-induced nuclear translocation of STAT3 immunoreactivity in hypothalamic nuclei involved in body weight regulation. J Neurosci 21:2413-2424, 2001 https://doi.org/10.1523/JNEUROSCI.21-07-02413.2001
  34. Hosoi T, Kawagishi T, Okuma Y, Tanaka J, Nomura Y: Brain stem is a direct target for leptin's action in the central nervous system. Endocrinology 143:34983504, 2002 https://doi.org/10.1210/en.143.6.2002
  35. Munzberg H, Flier JS, Bjorbaek C: Region-specific leptin resistance within the hypothalamus of diet-induced obese mice. Endocrinology 145(11):4880-4889, 2004 https://doi.org/10.1210/en.2004-0726
  36. Correia ML, Haynes WG, Rahmouni K, Morgan DA, Sivitz Wl, Mark AL: The concept of selective leptin resistance: evidence from agouti yellow obese mice. Diabetes 51:439-442, 2002 https://doi.org/10.2337/diabetes.51.2.439
  37. Ladyman SR, Grattan DR: Region-specific reduction in leptin-induced phosphorylation of signal transducer and activator of transcription-3 (STAT3) in the rat hypothalamus is associated with leptin resistance during pregnancy. Endocrinology 145:3704-3711, 2004 https://doi.org/10.1210/en.2004-0338
  38. Tups A, Ellis C, Moar KM, Logie TJ, Adam CL, Mercer JG, Klingenspor M: Photoperiodic regulation of leptin sensitivity in the Siberian hamster, Phodopus sungorus, is reflected in arcuate nucleus SOCS- 3 (suppressor of cytokine signaling) gene expression. Endocrinology 145(3):1185-1193, 2004 https://doi.org/10.1210/en.2003-1382
  39. Oral EA, Simha V, Ruiz E, Andewelt A, Premkumar A, Snell P, Wagner AJ, DePaoli AM, Reitman ML, Taylor SI, Gorden P, Garg A: Leptin-replacement therapy for lipodystrophy. N Engl J Med 346(8):570-578, 2002 https://doi.org/10.1056/NEJMoa012437
  40. Cochran E, Young JR, Sebring N, DePaoli A, Oral EA, Gorden P: Efficacy of recombinant methionyl human leptin therapy for the extreme insulin resistance of the Rabson-Mendenhall syndrome. J Clin Endocrinol Metab 89(4): 1548-1554, 2004 https://doi.org/10.1210/jc.2003-031952
  41. Petersen KF, Oral EA, Dufour S, Befroy D, Ariyan C, Yu C, Cline GW, DePaoli AM, Taylor SI, Gorden P, Shulman GI: Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy. J Clin Invest 109(10):1345-1350, 2002 https://doi.org/10.1172/JCI0215001
  42. Welt CK, Chan JL, Bullen J, Murphy R, Smith P, DePaoli AM, Karalis A, Mantzoros CS: Recombinant human leptin in women with hypothalamic amenorrhea. N Engl J Med 351(10):987-997, 2004 https://doi.org/10.1056/NEJMoa040388
  43. Zelissen PM, Stenlof K, Lean ME, Fogteloo J, Keulen ET, Wilding J, Finer N, Rossner S, Lawrence E, Fletcher C, McCamish M: Effect of three treatment schedules of recombinant methionyl human leptin on body weight in obese adults: a randomized, placebo- controlled trial. Diabetes Obes Metab 7(6):755-761, 2005 https://doi.org/10.1111/j.1463-1326.2005.00468.x
  44. Rosenbaum M, Goldsmith R, Bloomfield D, Magnano A, Weimer I., Heymsfield S, Gallagher D, Mayer I., Murphy E, Leibel RL: Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight. J Clin Invest 115(12):3579-3586, 2005 https://doi.org/10.1172/JCI25977
  45. Schurgin S, Canavan B, Koutkia P, Depaoli AM, Grinspoon S: Endocrine and metabolic effects of physiologic r-metHuLeptin administration during acute caloric deprivation in normal-weight women. J Clin Endocrinol Metab 89(11):5402-5409, 2004 https://doi.org/10.1210/jc.2004-1102