Experimental and Molecular Medicine

Korean Society for Biochemistry and Molecular Biongy (생화학분자생물학회)
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Swim training improves leptin receptor deficiency-induced obesity and lipid disorder by activating uncoupling proteins

Oh, Ki-Sook;Kim, Eun-Young;Yoon, Mi-Chung;Lee, Chung-Moo

  • Published : 20070600
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Abstract

Leptin receptor deficiency causes morbid obesity and hyperlipidemia in mice. Since physical exercise enhances energy expenditure, it is an important part of successful weight-control regimens. We investi-gated the mechanism by which swim training regulates leptin receptor deficiency-induced obesity and lipid disorder in a mou se model of obesity (obese db/db mouse). Swim training for 6 weeks significantly decreased body weight gain and adipose tissue mass in both sexes of obese and lean mice, compared to their respective sedentary controls. These effects were particularly evident in obese mice. Swim training also caused significant decreases in serum cholesterol in both obese and lean mice. In obese mice, swim training increased the levels of mRNAs and proteins encoding unc oupling protein 1 (UCP1), UCP2 and UCP3 in brown adipose tissue, white adipose tissue and skeletal muscle, respectively. In conclusion, these findings suggest that, in mice, swim training can effectively prevent body weight gain, adiposity and lipid di sorders caused by leptin receptor deficiency, in part through activation of UCPs in adipose tissue and skeletal muscle, which may contribute to alleviating metabolic syndromes, such as obesity, hyperlipid emia and type 2 diabetes.

Keywords

References

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