한국체육학회지자연과학편

Korean Alliance for Health: Physical Education: Recreation:and Dance (한국체육학회)
권호 표지

Effect of exercise training on expression of GLUT 1 and GLUT 3 protein in the hippocampus of streptozotocin-induced diabetic rats

운동훈련이 당뇨유발 흰쥐 뇌의 해마에서 GLUT 1과 GLUT 3 단백질 발현에 미치는 영향

Jeong, Il-Gyu;Yoon, Jin-Hwan;Lee, Hee-Hyuk;Kim, Jong-Oh;Seo, Tae-Beom;Oh, Myung-Jin
정일규;윤진환;이희혁;김종오;서태범;오명진

  • Published : 2007.03.31
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Abstract

The purpose of this study was to examine the effect of exercise training on GLUT 1 and GLUT 3 protein expression in the hippocampus of streptozotocin (STZ)-induced diabetic rats. Sprague-Dawley rats were randomly divided into three groups: control group (n=6), STZ-induced diabetes group (n=6), and STZ-induced diabetes and exercise group (n=6). Rats in the exercise group were made to run on a motorized treadmill for 30 min once a day for 4 weeks. GLUT 1 and GLUT 3 protein expression in the hippocampus was analyzed by Western blotting. GLUT 1 level in STZ-induced diabetes group was significantly higher than that in control group(p<.05). Exercise training in STZ-induced diabetic rats induced a significant increase compared with STZ-induced diabetic rats(p<.05). However, GLUT 3 level did not differ significantly among three groups. In conclusion, these results suggest that the STZ-induced diabetes may result in a compensatory increase of GLUT 1 protein expression in the rat hippocampus, and exercise training may contribute to an compensatory up-regulation of GLUT 1 protein expression in STZ-induced diabetic rats.

Keywords

References

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