Annals of Laboratory Medicine

Korean Society for Laboratory Medicine (대한진단검사의학회)
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Inflammatory Marker Expression and Its Implication in Korean Ischemic Stroke Patients

한국인 허혈성 뇌중풍 환자에서 염증표지자의 발현 양상

Park, Su-Yon;Kim, Meoung-Hee;Kang, So-Young;Suh, Jin-Tae;Lee, Woo-In
박수연;김명희;강소영;서진태;이우인

  • Published : 2007.06.30
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Abstract

배경 : 허혈성 뇌중풍은 염증반응, 환경적 및 유전적 요인 등에의해 영향을 받는 복합적 상태이다. 이러한 관련 위험요인들을 밝혀내는 것이 뇌중풍의 원인 및 기전, 진단 그리고 치료를 이해하는데 중요하다. 아직까지 이들 표지자의 정확한 작용이나 의의에대해서는 논란이 있으며 더욱이 한국인을 대상으로 이러한 표지자들의 통합적인 연구는 아직 이루어진 적이 없다. 이에 저자들은한국인 허혈성 뇌중풍 환자들을 대상으로 염증 표지자들의 발현양상을 보고자 하였고 나아가 잘 알려진 유전적 요인인 아포 E단백의 다형성과의 관계를 알아보고자 하였다. 방법 : 총 275명의 허혈성 뇌중풍 환자들과 19명의 건강한 대조군을 대상으로 하였다. 환자군은 169명의 LA (large arteryatherosclerosis)군과 106명의 SAO (small artery occlusion)군으로 분류하여 비교하였다. 염증 표지자 matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1 (TIMP-1)와 high-sensitivity C-reactive protein (hsCRP)의 혈장 농도를측정하였다.결과 : 모든 염증 표지자, 특히 MMP-9와 hs-CRP가 대조군에 비해 환자군에서 높게 측정되었다. 또한 환자군 내의 서로 다른 기전을 지닌 두 군을 비교한 결과 TIMP-1만 LAA군에서 유의하게 높게 측정되었다. 각 특정 아포 E 단백 이형접합체간에염증 표지자의 수치에는 유의한 차이가 관찰되지 않았다.

Keywords

References

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