Laboraroty Animal Research

Korean Association for Laboratory Animal Science (한국실험동물학회)
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Hematological and Blood Biochemical Values of Laboratory Beagle Dogs

Jeong, Eun-Ju;Han, Su-Cheol;Cha, Shin-Woo;Lee, Hyun-Sook;Ha, Chang-Su;Kim, Choong-Yong

  • Published : 20070900
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Abstract

To provide a historical control data in Beagle dogs for the selection criteria of animals in toxicology, pharmacology and pharmacokinetic studies including bioequivalence studies, 15 hematological and 19 blood biochemical values from 372 Beagle dogs (186 dogs/sex, 6-7.5 months of age) were evaluated and compared with available literature values. Data listed include the mean, standard deviation, maximum, minimum, 10th and 90th percentiles of each parameter per sex to help screening of data. High individual variations were noted in leukocyte counts, % of neutrophils, lymphocytes and reticulocytes, platelets, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total bilirubin, total cholesterol, triglyceride, phospholipid, albumin/globulin ratio, blood urea nitrogen, creatinine, creatine phosphokinase and inorganic phosphorus. Sex-related differences were found in erythrocyte count, hemoglobin, hematocrit, alkaline phosphatase, total cholesterol, phospholipid, albumin/globulin ratio, blood urea nitrogen, creatine phosphokinase, inorganic phosphorous and potassium. Age-related differences were observed in % of lymphocytes, basophils, eosinophils and reticulocytes, aspartate aminotransferase, alkaline phosphatase, triglyceride and total bilirubin. Since hematological and blood biochemical values are influenced by factors such as sex and age, sex-related differences and age-related changes should be carefully considered when interpreting data.

Keywords

References

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