Clinical and Molecular Hepatology (대한간학회지)

The Korean Association for the Study of the Liver (대한간학회)
권호 표지

The Role of Activated Hepatic Stellate Cells in Liver Fibrosis, Portal Hypertension and Cancer Angiogenesis

간섬유화, 문맥압항진증 및 간암 혈관생성 과정에서 활성화된 간 성상세포의 역할

Lee, June-Sung;Kim, Jong-Hoon
이준성;김종훈

  • Published : 2007.09.25
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Abstract

Although hepatic stellate cells, which are liver specific pehcytes, have been recognized within thevasculature of the sinusoid for more than one hundred years, the biology and function of these cellsis unclear. Recent studies have highlighted the key role of stellate cells in a number of fundamentalprocesses that include wound healing/fibrosis, vasoregulation, and vascular remodeling/angiogenesis. Inthe liver, these processes are particularly important in the development of cirrhosis, Portal hypertensionand cancer. This article highlights the recent advances in our understanding of the biology of hepaticstellate cells and discusses some of the recently-ascribed functions that are relevant to liver fibrosis,portal hypertension and cancer angiogenesis. (Korean J Hepatol 2007;13:309 319)

Keywords

References

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