KSBB Journal

The Korean Society for Biotechnology and Bioengineering (한국생물공학회)
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Anti-obesity Effects of Ginsenoside Rd via AMPK and PPAR Gamma

진세노사이드 Rd의 AMPK 및 PPAR 감마의 신호전달경로를 통한 항비만효과

  • Kim, Myung-Sunny (Food Function Research Center, Food Convergence Technology Division, Korea Food Research Institute) ;
  • Lee, Myoung-Soo (Food Function Research Center, Food Convergence Technology Division, Korea Food Research Institute) ;
  • Kim, Soon-Hee (Food Function Research Center, Food Convergence Technology Division, Korea Food Research Institute) ;
  • Kim, Sung-Hee (Food Function Research Center, Food Convergence Technology Division, Korea Food Research Institute) ;
  • Kim, Hyun-Jin (Food Function Research Center, Food Convergence Technology Division, Korea Food Research Institute) ;
  • Sung, Mi-Jeong (Food Function Research Center, Food Convergence Technology Division, Korea Food Research Institute) ;
  • Kim, Hye-Young (Food Function Research Center, Food Convergence Technology Division, Korea Food Research Institute) ;
  • Kwon, Dae-Young (Food Function Research Center, Food Convergence Technology Division, Korea Food Research Institute) ;
  • Hwang, Jin-Taek (Food Function Research Center, Food Convergence Technology Division, Korea Food Research Institute)
  • 김명선 (한국식품연구원 식품 융.복합본부, 기능성연구단) ;
  • 이명수 (한국식품연구원 식품 융.복합본부, 기능성연구단) ;
  • 김순희 (한국식품연구원 식품 융.복합본부, 기능성연구단) ;
  • 김성희 (한국식품연구원 식품 융.복합본부, 기능성연구단) ;
  • 김현진 (한국식품연구원 식품 융.복합본부, 기능성연구단) ;
  • 성미정 (한국식품연구원 식품 융.복합본부, 기능성연구단) ;
  • 김혜영 (한국식품연구원 식품 융.복합본부, 기능성연구단) ;
  • 권대영 (한국식품연구원 식품 융.복합본부, 기능성연구단) ;
  • 황진택 (한국식품연구원 식품 융.복합본부, 기능성연구단)
  • Published : 2007.10.30
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Abstract

Obesity is a major obstacle for human health, which induces various diseases such as cardiac injury and type 2 diabetes. Ginsenosides, active components of ginseng extract, exert various physiological effects. However, There are still no evidence for their anti obesity effects. In this study, we investigated the effects of ginsenoside Rd on adipocyte differentiation in 3T3-L1 cells. Our data show that ginsenoside Rd (80 uM) was effective in adipocyte differentiation inhibition. These inhibitory effects of ginsenosides on adipocyte differentiation were accompanied by PPAR gamma inhibition in rosiglitazone-treated cells. We also tested whether AMP-activated protein kinase (AMPK) activation was involved in the effects of these ginsenosides. AMPK is a master target for obesity, ginsenoside Rd significantly activated AMPK. Taken together, these results suggest that the anti obesity effects of ginsenoside Rd involve the AMPK signaling pathway and PPAR-gamma inhibition.

진세노사이드 Rd가 지방세포분화에 미치는 영향을 관찰한 결과 다음과 같은 결론을 얻었다. 1. 진세노사이드 Rd는 3T-L1지방세포모델에 있어 효과적으로 지방분화를 억제한다. 2. 진세노사이드 Rd는 세포내 에너지대사의 필수 단백질인 AMPK를 활성화시키고 또한 지방분화과정에 발현 및 활성이 증가하는 PPAR 감마의 활성을 효과적으로 억제한다. 이상의 결과로 진세노사이드 Rd는 세포내 에너지대사를 촉진하여 지방축적 억제에 탁월한 효과를 보일 것으로 사료된다.

Keywords

References

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