Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
권호 표지

Effect of Lecithin Intake on Lipid Metabolism and Antioxidative Capacity in Rats Fed High Fat Diet

레시틴섭취가 고지방 식이를 섭취한 흰쥐의 지방대사와 항산화능에 미치는 영향

  • Yang, Su-Young (Department of Food & Nutritional Sciences, Ewha Womans University) ;
  • Hong, So-Young (Department of Food & Nutritional Sciences, Ewha Womans University) ;
  • Sung, Mi-Kyung (Department of Food & Nutrition, Sookmyung Womans University) ;
  • Kang, Myung-Hee (Department of Food & Nutrition, Hannam University) ;
  • Kim, Mi-Kyung (Department of Food & Nutritional Sciences, Ewha Womans University)
  • 양수영 (이화여자대학교 식품영양학과) ;
  • 홍소영 (이화여자대학교 식품영양학과) ;
  • 성미경 (숙명여자대학교 식품영양학과) ;
  • 강명희 (한남대학교 식품영양학과) ;
  • 김미경 (이화여자대학교 식품영양학과)
  • Published : 2007.06.30
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Abstract

This study was performed to investigate the effect of lecithin on lipid metabolism and antixidative capacity in 9-week-old rats. Forty-five male Sprague-Dawley rats weighing 249.8 g were blocked into three groups according to their body weight and raised for 8 weeks with experimental diets containing 1% (LM) or 5% lecithin (LH) and control (C) diet. Plasma and liver total lipids, triglyceride, total cholesterol and plasma HDL-cholesterol concenterations, and fecal total lipids, triglyceride, total cholesterol and bile acid excretions were measured. Malondialdehyde (MDA) levels in plasma, liver, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities in red blood cell and liver, xanthine oxidase (XO) activities in plasma and liver, and total antioxidant status (TAS) in plasma were also measured. Effect of lecithin intake on antioxidative capacity was not significantly different among all the groups. Plasma total lipids, triglyceride and total cholesterol levels were lower in lecithin groups compared to control group, and these three lipid levels of lecithin groups were lowered dose-dependently as dietary lecithin level increased. But liver total lipids, triglyceride and total cholesterol levels were not different among all the groups. Also fecal total lipids, triglyceride and total cholesterol excretions were highest in high lecithin groups compared to two other groups. Thus it is plausible that lecithin intake decreases plasma lipid levels through increasing fecal lipid excretions, and may be beneficial for treatment and prevention of hyperlipidemia, but has no effect on antioxidative capacity.

Keywords

References

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