Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Induction of Enhancement of Anti-Tumor Immunity by Polysaccharides Fractionated from Acanthopanx Senticosus

가시오가피 다당체에 의한 항종양면역의 유도

  • Yoon, Taek-Joon (Dept. of Food & Nutrition, Yuhan College) ;
  • Sung, Ji-Yeon (Food Business R&D, Boryung Co., Ltd.) ;
  • Yu, Kwang-Won (Department of Food Science & Biotechnology, Chungju National University) ;
  • Lee, Ho (Department of Food Science & Biotechnology, Kyounggi University) ;
  • Lee, Kwang-Ho (Department of Biotechnology, College of Biomedical and Health Science, Konkuk University)
  • 윤택준 (유한대학 식품영양학과) ;
  • 성지연 ((주)보령제약) ;
  • 유광원 (충주대학교 식품생명공학부) ;
  • 이호 (경기대학교 식품생물공학부) ;
  • 이광호 (건국대학교 의료생명대학 생명공학전공)
  • Published : 2007.06.30
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Abstract

The specific activation of the immune system to control cancer growth in vivo has been a long-standing goal in cancer immunology. Whole tumor Iysates have been used either alone or combined with adjuvants to induce specific immune response in vivo. Here, we examined whether freezing/thawing (F/T) colon26-M3.1 tumor cell admixed with EN-3, glycoprotein purified from Acanthopanx Senticosus, could stimulate in vivo immunity by using a murine experimental tumor metastasis model produced by colon26-M3.1 carcinoma cells. Vaccination of mice with F/T treated colon26-M3.1 carcinoma cells in combination with EN-3 as an adjuvant resulted in a significant inhibition in tumor metastasis of mice against live colon26-M3.1 carcinoma challenge. In addition, the splenocytes from vaccinated mice exhibited a higher proliferating activity and secreted interferon-${\gamma}$. These results suggest that EN-3 can be applied to immunoadjuvant to enhance the antitumor immunity in vivo.

Keywords

References

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