Korean Journal of Oriental Medicine (한국한의학연구원논문집)
- Volume 13 Issue 3
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- Pages.151-156
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- 2007
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- 1229-3377(pISSN)
Subacute Toxicity Study on Sagunja-tang(Sijunzi-tang) in SD Rats
SD 랫트를 이용하여 사군자탕(四君子湯)의 아급성 독성에 관한 연구
-
Ma, Jin-Yeul
(Korea Institute of Oriental Medicine)
;
- Yu, Young-Beob (Korea Institute of Oriental Medicine) ;
-
Ha, Hye-Kyung
(Korea Institute of Oriental Medicine)
;
- Huang, Dae-Sun (Korea Institute of Oriental Medicine) ;
-
Shin, Hyun-Kyoo
(Korea Institute of Oriental Medicine)
- Published : 2007.12.30
Abstract
Sagunja-tang(Sijunzi-tang) has been traditionally prescribed as a restorative. The present study was undertaken to determine the possible toxic effects of Sagunja-tang on SD rats. In this study, we investigated the subacute toxicity of water-extracted Sagunja-tang(Sijunzi-tang) on SD rats. Twenty rats were orally adiministered Sagunja-tang for 28 days at a dose of 0 mg/kg(control group) or 1500mg/kg(treated group), respectively. All of subjects was survived. No significant difference in abnormal clinical signs, related to hematological values, serum biochemical values, water and feed intake, coagulation time, autopsy analysis, organ weight, tissue microscopically, funduscopy, urine intake and urinalysis, was detected. Compared with the control group, we could not find any subacute toxic alteration in treated group (1500mg/kg) for 28 days. This result suggests that Sagunja-tang(Sijunzi-tang). a herbal medicine prescription, is a safe prescription to body.