Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Therapeutic Effect of Hovenia dulcis Thunberg Extracts and 6 Types Herbal Extracts on $CCl_4-induced$ Chronic Organ Damages in the Rats-Liver and Kidney

Carbon Tetrachlorid으로 유발된 Rat의 만성 장기(간, 신장) 손상시 헛개나무열매 추출물등 6종 생약의 투여시 조직병리학적변화

  • Lim, Mee-Kyoung (Department of Food Science and Nutrition, School of Human Ecology, Kyungpook National University) ;
  • Kim, Joo-Wan (Department of Internal Medicine, School of Veterinary Medicine, Kyungpook National University) ;
  • Kim, Hong-Tae (Busan Metropolitan City Institute of Health and Environment) ;
  • Lee, Byoung-Je (Department of Internal Medicine, School of Veterinary Medicine, Kyungpook National University) ;
  • Ku, Sae-Kwang (Daegu Haany University Oriental Medicine) ;
  • Kang, Mi-Young (Department of Food Science and Nutrition, School of Human Ecology, Kyungpook National University) ;
  • Lee, Keun-Woo (Department of Internal Medicine, School of Veterinary Medicine, Kyungpook National University)
  • 임미경 (경북대학교 생활과학대학) ;
  • 김주완 (경북대학교 수의과대학) ;
  • 김홍태 (부산광역시 보건환경연구원) ;
  • 이병제 (경북대학교 수의과대학) ;
  • 구세광 (대구한의대학교 한의학과) ;
  • 강미영 (경북대학교 생활과학대학) ;
  • 이근우 (경북대학교 수의과대학)
  • Published : 2007.09.30
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Abstract

This study was conducted to clarify the effects of the Korean raisin (Hovenia dulcis Thunb) extracts and polyherbal extracts consisted of 6 types herbal extracts including HDT (HDTmix) on $CCl_4$ induced organ damages. Extracts were prepared by autoclave ($121^{\circ}C$, 15 psi, 3 hours) and filtered with nylon cloth and filter paper then freezing dried. Male Sprague-Dawley rats $(200^{\circ}{\ae}20g)$ were used as experimental groups, which were divided into 5 groups; intact control group (100 mg/kg), $CCl_4$ dosing group (100 mg/kg), $CCl_4$ dosing after HDT extract dosing group (100 mg/kg), $CCl_4$ dosing after HDTmix dosing group (100 mg/kg), Silymarin dosing group (5 mg/kg) after all test articles were orally dosed once a day for 28 days. They were sacrifiled under ether anesthesia. HDT extracts and HDTmix dramatically inhibits the $CCl_4$ intoxicated hepato/nephropathies with immuno-suppress changes on the spleen. They showed more dramatical protective effects on most of specific organs compared to that of Silymarin 5 mg/kg except for hepatoprotective effects in which, quite similar effects were detected. In addition, HDT extracts showed synergic effects with other types of herbal extracts because HDTmix showed more favorable protective effects on the all specific organs showing $CCl_4-related$ histopathological changes compared to HDT extracts.

Keywords

References

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