The Journal of Korean Obstetrics and Gynecology (대한한방부인과학회지)

The Society of Korean Medicine Obstetrics and Gynecology (대한한방부인과학회)
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A study on effects of Ligustri Lucidi Fructus, Ecliptae Herba and Yijihwan on antioxidant activity and blood pressure

여정자(女貞子), 한연초(旱蓮草) 및 이지환(二至丸)의 항산화활성 및 혈압에 미치는 영향에 관한 연구

  • Kang, Seung-Ho (Dept. of OB & GY, College of Oriental Medicine, Dongguk University) ;
  • Kim, Eun-Young (Food Chemistry and Biotechnology Division of Korea Food Research Institute) ;
  • Rhyu, Mee-Ra (Food Chemistry and Biotechnology Division of Korea Food Research Institute) ;
  • Kim, Dong-Il (Dept. of OB & GY, College of Oriental Medicine, Dongguk University)
  • 강승호 (동국대학교 한의과대학 한방부인과학교실) ;
  • 김은영 (한국식품연구개발원 생물공학연구부) ;
  • 류미라 (한국식품연구개발원 생물공학연구부) ;
  • 김동일 (동국대학교 한의과대학 한방부인과학교실)
  • Published : 2007.05.29
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Abstract

Purpose: Ligustri Lucidi Fructus and Ecliptae Herba has long been used for clinical therapy associated especially with menopausal symptoms in Korea. To provide a scientific rationale for such use, we have investigated the antioxidant and vasorelaxant effects of Ligustri Lucidi Fructus, Ecliptae Herba and its mixture. Methods: The antioxidant activity of the extracts from Ligustri Lucidi Fructus, Ecliptae Herba and its mixture were evaluated and compared with that of BHA (butylated hydroxyanisole), BHT (butylated hydroxytoluene), vitamin C and vitamin E, using the ${\alpha}$,${\alpha}-diphenyl-{\beta}-picrylhydrazyl$ (DPPH) radical scavenging method. Results: Antioxidant activity of all extracts using the DPPH radical scavenging method decreased in the order vitamin C>BHA>vitamin E>Ligustri Lucidi Fructus>Ligustri Lucidi Fructus:Ecliptae Herba(1:1)>Ecliptae Herba>BHT. The vasorelaxant effects of extracts were investigated on the vasomotor tone of the rat thoracic aorta in an organ bath. All of the extracts elicited along-term relaxing response in the endothelium-intact as well as endothelium-denuded rat aorta contracted with norepinephrine. This relaxant effect was abolished by Precontraction with 72 mM KCI. Thus, it is suggested that the mechanism of vasorelaxant effect of extracts not involve voltage-operated $Ca^{2+}$ channel blocking but receptor-mediated route. Conclusion: These antioxidant and vasorelaxant effecs of the extracts may contribute to the beneficial effects in postmenopausal women.

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