Journal of Oriental Neuropsychiatry (동의신경정신과학회지)

The Korean Society of Oriental Neuropsychiatry (대한한방신경정신과학회)
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Anti-obesity and Anti-hyperlipidemic Effects of Taeyeumjowee-tang and its modified prescription

태음조위탕(太陰調胃湯)과 그 가감방(加減方)의 항비만 및 항고지혈증 효과에 관한 연구

  • Kim, Kil-Soo (Dept. of Oriental Neuropsychiatry, College of Oriental Medicine, Dongguk University) ;
  • Lee, Dong-Ung (Dept. of Biotechnology, College of Science and Technology, Dongguk University) ;
  • Kim, Yong-Lae (Dept. of Oriental Neuropsychiatry, College of Oriental Medicine, Dongguk University) ;
  • Hwang, Moon-Je (Dept. of Oriental Neuropsychiatry, College of Oriental Medicine, Dongguk University) ;
  • Kim, Geun-Woo (Dept. of Oriental Neuropsychiatry, College of Oriental Medicine, Dongguk University) ;
  • Koo, Byung-Soo (Dept. of Oriental Neuropsychiatry, College of Oriental Medicine, Dongguk University)
  • 김길수 (동국대학교 한의과대학 신경정신과학교실) ;
  • 이동웅 (동국대학교 과학기술대학 생명공학과) ;
  • 김용래 (동국대학교 한의과대학 신경정신과학교실) ;
  • 황문제 (동국대학교 한의과대학 신경정신과학교실) ;
  • 김근우 (동국대학교 한의과대학 신경정신과학교실) ;
  • 구병수 (동국대학교 한의과대학 신경정신과학교실)
  • Published : 2007.07.30
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Abstract

Objective : The purpose of this study was to investigate the anti-obesity and anti-hyperlipidemic Effects of Taeyeumjowee-tang and its modified prescription on the animal model of obesity and hyperlipidemia induced high-fat diet. Method : 1) The extracts of Taeyeumjowee-tang (TJT) and its modified prescription, Taeyeumjoweetang gagam-bang (TJGB) were evaluated for its inhibitory effects on obesity. 2) The body weight and feed weight were determined in the pre-treated and post-treated mice and the lipid profiles in the serum were analyzed in order to evaluate the anti-hyperlipidemia action of the extracts. 3) The effect of each extract was investigated for the influences on monoamine oxidase activity and HMG-CoA reductase activity. Results 1. TJT and TJGB extracts dose-dependently reduced the body weight and feed intake in normal mice. The effect of TJGB extract was better than that of TJT extract. 2. TJGB extract diminished the body weight increase and reduced the feed intake in the pre-treatment or post-treatment of the extract 3. TJGB extract decreased the amount of total cholesterol slightly and triglyceride potently after the pre-treatment or post-treatment, but HDL cholesterol exhibited no remarkable change compared with control. 4. TJGB extract weakly potentiated the monoamine oxidase activity, but its effect was better than that of TJT extract. 5. TJGB extract weakly inhibited the HMG-CoA reductase activity, but its effect was better than that of TJT extract. Conclusion : Taeyeumjowee-tang and its modified prescription can clinically be useful as anti-obesity drug and also for the improvement of hyperlipidemia.

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