The Korea Journal of Herbology (대한본초학회지)
- Volume 22 Issue 2
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- Pages.147-153
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- 2007
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- 1229-1765(pISSN)
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- 2288-7199(eISSN)
ERK mediated suppressive effects of Sophora flavescens on Tnf alpha production in BV2 microglial cells
BV2 microglial cells에서 ERK를 통한 고삼의 Tnf alpha 생성 억제효과
- Kim, Soo-Cheol (Kohwang Medical Research Institute, College of Medicine, Kyung Hee University) ;
- Han, Mi-Young (Kohwang Medical Research Institute, College of Medicine, Kyung Hee University) ;
- Park, Hae-Jeong (Department of pharmacology, College of Medicine, KyungHee University) ;
- Jung, Kyung-Hee (Kohwang Medical Research Institute, College of Medicine, Kyung Hee University)
- Published : 2007.06.30
Abstract
Objectives : Sophora flavescens (SF) is widely used in traditional herbal medicine in Korea and is well recognized for its anti-inflammatory effect. However, its effect on Tumornecrosis factor alpha (Tnf) production in BV2 microglial cell is not yet known. Methods : We investigated the effect of SF on the production and expression of Tnf, a well known inflammatory mediator, in lipopolysaccaride (LPS)-activated BV2 microglial cells. Results : The LPS-induced Tnf production was markedly reduced by treatment with SF (50
Keywords
- Sophora flavescens;
- tumor necrosis factor alpha (Tnf);
- extracellular signal-regulated kinases (ERK);
- p38 mitogen activated protein kinase (p38 MAPK);
- c-Jun NH2-terminal kinases (JNK);
- inflammation