The Journal of Pediatrics of Korean Medicine (대한한방소아과학회지)

The Association of Korean Oriental Pediatrics (대한한방소아과학회)
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Effects of Kammaegdaejotang on the hemodynamic function in the isolated perfused rat heart

감맥대조탕(甘麥大棗湯)이 적출 흰쥐 심장의 혈역학적(血力學的) 기능(機能)에 미치는 영향(影響)

  • Kim, Deog-Gon (Department of Pediatrics, college of Oriental Medicine, Kyunghee University) ;
  • Park, Sung-Nam (Department of Pediatrics, college of Oriental Medicine, Kyunghee University)
  • 김덕곤 (경희대학교 한의과대학 소아과학교실) ;
  • 박성남 (경희대학교 한의과대학 소아과학교실)
  • Published : 2007.04.30
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Abstract

Objectives : In order to verify the cardiovascular hemodynamic function of Kammaegdaejo-tang, the experiment was performed in the rats. Methods : Twelve hearts removed from male Sparague-Dawley rats weighing between 250g and 300g were perfused by the Langendorff technique with modified 37 Krebs-Henseleit's buffer solution at a constant perfusion pressure. They were randomly assigned to one of two groups, supplied with either normal saline or Kammaegdaejotang administration. Heart rate, left ventricular pressure, +dp/dt maximum, -dp/dt maximum, and -dp/dt/ +dp/dt ratio were evaluated at baseline after the administration of either normal saline or Kammaegdaejotang. Results : Kammaegdaejotang made the heart rate increasing significantly (p<0.05). Kammaegdaejotang did not effectively work on left ventricular pressure of the isolated heart(p=0.11, no significance). The significant effects of Kammaegdaejotang were observed on +dp/dt max and -dp/dt max(p<0.05). Kammaegdaejotang did not effectively work on -dp/dt/ +dp/dt ratio(p=0.24, no significance).

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