Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Effects of Artemisia capillaris Methanol Extract on Organs in Tumor Cells Inoculated Mice Observed the Histopathology and Histomorphometry

조직병리학 및 Histomorphometry 기법으로 관찰한 종양 유발 마우스의 주요 장기에 인진쑥 Methanol 추출물이 미치는 영향

  • Kim, Hong-Tae (Busan Metropolitan City Institute of Health and Environment) ;
  • Ku, Sae-Kwang (College of Oriental Medicine, Daegu Haany University) ;
  • Kim, Ju-Wan (College of Veterinary Medicine, Kyungpook National University) ;
  • Jin, Tae-Won (College of Veterinary Medicine, Kyungpook National University) ;
  • Lim, Mee-Kyung (College of Human Ecology, Kyungpook National University) ;
  • Kim, Ji-Eun (Department of Biotechnology, Daegu University) ;
  • Chang, Hye-Sook (Busan Regional Korea Food & Drug Administration) ;
  • Yeo, Sang-Geon (College of Veterinary Medicine, Kyungpook National University) ;
  • Jang, Kwang-Ho (College of Veterinary Medicine, Kyungpook National University) ;
  • Oh, Tae-Ho (College of Veterinary Medicine, Kyungpook National University) ;
  • Lee, Keun-Woo (College of Veterinary Medicine, Kyungpook National University)
  • 김흥태 (부산광역시 보건환경연구원) ;
  • 구세광 (대구한의대학교 한의과대학) ;
  • 김주완 (경북대학교 수의과대학) ;
  • 진태원 (경북대학교 수의과대학) ;
  • 임미경 (경북대학교 생활과학대학) ;
  • 김지은 (대구대학교 생명공학과) ;
  • 장혜숙 (부산지방식품의약품안전청) ;
  • 여상건 (경북대학교 수의과대학) ;
  • 장광호 (경북대학교 수의과대학) ;
  • 오태호 (경북대학교 수의과대학) ;
  • 이근우 (경북대학교 수의과대학)
  • Published : 2008.08.31
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Abstract

This experiment was conducted to investigate antitumor and immunomodulatory effects of Artemisia capillaris extracts against Hepa-lc1c7 and Sarcoma 180 cancer cells. In in vivo experimental tests using 210 ICR mice, on the $28^{th}$ day and the $42^{nd}$ day, all animals in vehicle controled HP (Hepa-lclc7 tumor cell inoculated vehicle control) and SP (Sarcoma 180 tumor cell inoculated vehicle control) showed tumor cells in the liver and spleen based on the histopathology. However, the incidences and the percentages of regions occupied by tumor cells were dramatically and dose-dependently decreased by mACH (Artemisia capillaris methanol extracts) treatment on the histomorphometry. Although the exact mechanism of inhibition of the incidences of tumor cells in the parenchyma whether inhibition of metastasis or proliferation is unclear, mACH dramatically reduce the percentages of regions occupied by tumor cells in the liver and spleen apart from the inoculation sites of Hepa-lclc7 and Sarcoma 180. In addition, they also effectively inhibit the abnormal changes on the kidney detected in the present study. The results suggest that Artemisia capillaris methanol extracts have prominent antitumor effects on the cancer cell lines Hepa-lclc7 and Sarcoma 180 m mice.

Keywords

References

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