The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Effects of Rhodiola Rosea on Anti-Fatigue and Hypothalamic IEGs Expressions of Forced Swimming Rats

홍경천(紅景天)이 강제유영 흰쥐의 항피로 및 시상하부 IEGs 발현에 미치는 영향

  • Ryu, Sa-Hyun (Dept. of Neuroscience and Brain Disease, Graduate School of East-West Medicine, Kyung Hee University) ;
  • Kim, Sun-Yeou (Dept. of Neuroscience and Brain Disease, Graduate School of East-West Medicine, Kyung Hee University) ;
  • Jung, Hyuk-Sang (Dept. of Anatomy & Institute of Oriental Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Sohn, Nak-Won (Dept. of Neuroscience and Brain Disease, Graduate School of East-West Medicine, Kyung Hee University) ;
  • Sohn, Young-Joo (Dept. of Gynecology, College of Oriental Medicine, Sangji University)
  • 류사현 (경희대학교 동서의학대학원 신경과학 및 뇌질환) ;
  • 김선여 (경희대학교 동서의학대학원 신경과학 및 뇌질환) ;
  • 정혁상 (경희대학교 한의과대학 해부학교실, 한의학연구소) ;
  • 손낙원 (경희대학교 동서의학대학원 신경과학 및 뇌질환) ;
  • 손영주 (상지대학교 한의과대학 부인과학교실)
  • Published : 2008.12.30
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Abstract

Objectives: In this study the authors investigated effects of the ethanolic extract of Rhodjola Rosea(HKC) on fatigue and hypothalamic IEG expression in rat forced swimming(FS) model. Methods: Sprague-Dawley rats were administered HKC extract(25 mg/100g, p.o.) for 3 days prior to FS, some rats underwent 10 min FS and others exhaustive forced swimming(EFS). In addition, other rats were administered extract at different times after EFS over 3 consecutive days. Results: When HKC administered before 10 mins of FS, serum actate dehydrogenase(LDH) and creatine phosphokinase(CPK) activities were significantly lower than control group. When HKC administered prior to EFS, blood lactate was significantly lower versus control group. When HKC was administered after EFS, blood lactate(at 6 and 24 hours after EFS) were significantly lower and serum LDH, CPK activities(at 24 hours after EFS) were significantly lower versus control group. When HKC was administered after EFS, c-Fos positive neurons in hypothalamic periventricular area(PVA), medial part(mPVN) and anterior hypothalamic nucleus caudal part(AHC) were significantly lower at 24 hours after EFS than in control group. HSP-72 positive neuron numbers in hypothalamus were significantly lower at 24 hours after EFS than in control group. Finally, when HKC was administered prior to 10 mins FS, HIF-$1{\alpha}$ expression in the gastrocnemius muscle was significantly increased. Conclusions: These results suggest that HKC extract has an anti-fatigue effect, and it reduces neuronal cell stress responses induced by physical stress by having a beneficial effect on lactate metabolism.

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